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Hydroxyethyl cellulose

Catalog No. T19362 CAS 9004-62-0

Synonyms: Cellulose hydroxyethyl ether, 2-Hydroxyethyl cellulose

Hydroxyethyl cellulose (2-Hydroxyethyl cellulose) is a nonionic water-soluble modified cellulose polymer used as a thickener in water-soluble cosmetics and personal care formulations.

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Hydroxyethyl cellulose Chemical Structure

Hydroxyethyl cellulose, CAS 9004-62-0

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Hydroxyethyl cellulose (2-Hydroxyethyl cellulose) is a nonionic water-soluble modified cellulose polymer used as a thickener in water-soluble cosmetics and personal care formulations.

In vitro

Hydroxyethyl cellulose demonstrates outstanding cryoprotective effects on lactate dehydrogenase (LDH) during freeze-thaw cycles and significant lyoprotective effects throughout the freeze-drying process. The annealing process minimally affects its stabilizing capabilities. However, the lengthy reconstitution times for hydroxyethyl cellulose lyophilisates are significantly reduced by adding the surfactant Tween 80 before freeze-drying. Furthermore, hydroxyethyl cellulose is utilized to stabilize graphene oxide in physiological solutions, enhancing its suitability for targeted drug delivery. It effectively stabilizes graphene oxide in electrolyte solutions, with the stabilization mechanism being influenced by the hydroxyethyl cellulose content. This content is crucial in tailoring the nanohybrid for specific applications, whether for controlled drug release or folate-targeted drug delivery.

Synonyms	Cellulose hydroxyethyl ether, 2-Hydroxyethyl cellulose
Molecular Weight	N/A
CAS No.	9004-62-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 9.09 mg/mL, Heating to 93℃ is recommended.

DMSO: 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Mianehrow H, et al. Graphene-oxide stabilization in electrolyte solutions using hydroxyethyl cellulose for drug delivery application. Int J Pharm. 2015 Apr 30;484(1-2):276-82. 2. Al-Hussein A, et al. Investigation of the stabilizing effects of hydroxyethyl cellulose on LDH during freeze drying and freeze thawing cycles. Pharm Dev Technol. 2015 Jan;20(1):50-9.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Hydroxyethyl cellulose 9004-62-0 Others inhibit Inhibitor Cellulose hydroxyethyl ether 2-Hydroxyethyl cellulose inhibitor

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