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Histamine Phosphate

Catalog No. T6535 CAS 51-74-1

Synonyms: Histamine diphosphate, Histamine acid phosphate

Histamine Phosphate (Histamine acid phosphate) acts directly on the blood vessels to dilate arteries and capillaries mediated by both H 1- and H 2-receptors.

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Histamine Phosphate, CAS 51-74-1

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Description	Histamine Phosphate (Histamine acid phosphate) acts directly on the blood vessels to dilate arteries and capillaries mediated by both H 1- and H 2-receptors.
In vitro	Histamine (10 μM) gives a larger inositol monophosphate accumulation in bovine adrenal chromaffin cells. Histamine (10 μM) stimulates the level of radioactivity into the InsP3-containing fraction in bovine adrenal chromaffin cells. Histamine (100 μM) stimulates incorporation into the InsP3-containing eluate in a less extent than for angiotensin I1 and bradykinin. [1]
In vivo	Histamine phosphate (0.025 mg/kg) produces a mean increase in basilar blood flow of 145% of control in dogs. Histamine phosphate produces considerable increases in basilar blood flow as well as a decrease in femoral arterial blood pressure in dogs when injected intravenously and measured with an electromagnetic flow transducer. [2] Histamine phosphate (4 μg/kg) causes lymph flow to increase from 6.0 to 27.0 (SEM) ml/h in unanesthetized sheep. Histamine phosphate (4 μg/kg) also causes increases in lung water, pulmonary vascular resistance, arterial PCO2, pH, and hematocrit, and decreases in cardiac output and arterial PO2 in unanesthetized sheep. [3] Histamine phosphate (8.3 mg/kg/min) causes no significant change in pulmonary lymph flow (QL) or protein concentration (CL) in anesthetized open-chested dogs, however, both are increased after alloxan. Histamine phosphate (8.3 mg/kg/min) also causes no significant change in the pulmonary capillary membrane filtration coefficient (Kf) and the maximum capillary pressure (PCcritical) in anesthetized open-chested dogs. [4] Histamine phosphate (50 mg/kg) produces a pronounced rise in acid secretion but the output of pepsin remained unchanged in the unanaesthetized intact rat. Histamine phosphate (50 mg/kg) produces maximal stimulation of gastric acid secretion and is free from toxic effects in the unanaesthetized intact rat. [5]

Synonyms	Histamine diphosphate, Histamine acid phosphate
Molecular Weight	307.14
Formula	C5H9N·2H3O4P
CAS No.	51-74-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 10 mM

DMSO: Insoluble

References and Literature

1. Plevin R, et al. J Neurochem, 1988, 51(2), 634-641. 2. Anderson WD, et al. Stroke, 1971, 2(4), 409-415. 3. Brigham KL, et al. J Clin Invest, 1976, 58(2), 391-398. 4. Drake RE, et al. Am J Physiol, 1980, 239(1), H96-100. 5. VALBERG LS, et al. Gut, 1961, 2, 32-36.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Clinical Compound Library RO5 Drug-like Natural Product Library Anti-Cancer Compound Library Histamine & Melatonin Receptor-Targeted Compound Library Anti-Tumor Natural Product Library Alkaloid Natural Product Library Neurotransmitter Receptor Compound Library Natural Product Library for HTS

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Keywords

Histamine Phosphate 51-74-1 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor inhibit Inhibitor Histamine diphosphate Histamine acid Phosphate Histamine Diphosphate Histamine acid phosphate Histamine inhibitor

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