store at low temperture
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Hematein inhibits <a href="/target/Akt" style="display: inline; color: #c13a36">Akt</a>/PKB Ser129 phosphorylation, the Wnt/TCF pathway, and increases <a href="/pathway/Apoptosis" style="display: inline; color: #c13a36">Apoptosis</a> in lung cancer cells. Hematein is an oxidation product of hematoxylin acted as a dye and it also is an allosteric <a href="/target/Casein_Kinase" style="display: inline; color: #c13a36">Casein Kinase</a> II inhibitor (IC50: 0.74 μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
50 mg | In stock | $ 50.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 57.00 |
Description | Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway, and increases apoptosis in lung cancer cells. Hematein is an oxidation product of hematoxylin acted as a dye and it also is an allosteric casein kinase II inhibitor (IC50: 0.74 μM). |
Targets&IC50 | CKII:0.74 μM |
In vitro | Hematein (50 and 100 μM; 48 hours) inhibits CK2-specific Akt phosphorylation. Hematein (50 and 100 μM; 48 hours) causes apoptosis in A427 lung cancer cells. Hematein (10-100 μM; 14 days) inhibits cell growth in A427 lung cancer cells [1]. |
In vivo | In A427 lung cancer cell xenografts, Hematein (i.p.; 50 mg/kg; twice a week for 6 weeks) inhibits tumor growth [1]. |
Synonyms | Hydroxybrasilein |
Molecular Weight | 300.266 |
Formula | C16H12O6 |
CAS No. | 475-25-2 |
store at low temperture
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Hematein 475-25-2 Cytoskeletal Signaling PI3K/Akt/mTOR signaling Stem Cells Wnt/beta-catenin Akt Hydroxybrasilein Inhibitor inhibitor inhibit