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Hematein

Catalog No. T15469 CAS 475-25-2

Synonyms: Hydroxybrasilein

Hematein inhibits <a href="/target/Akt" style="display: inline; color: #c13a36">Akt</a>/PKB Ser129 phosphorylation, the Wnt/TCF pathway, and increases <a href="/pathway/Apoptosis" style="display: inline; color: #c13a36">Apoptosis</a> in lung cancer cells. Hematein is an oxidation product of hematoxylin acted as a dye and it also is an allosteric <a href="/target/Casein_Kinase" style="display: inline; color: #c13a36">Casein Kinase</a> II inhibitor (IC50: 0.74 μM).

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Hematein, CAS 475-25-2

Pack Size	Availability	Price/USD	Quantity
50 mg	In stock	$ 50.00
1 mL * 10 mM (in DMSO)	In stock	$ 57.00

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Purity: 98%

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Description	Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway, and increases apoptosis in lung cancer cells. Hematein is an oxidation product of hematoxylin acted as a dye and it also is an allosteric casein kinase II inhibitor (IC50: 0.74 μM).
Targets&IC50	CKII:0.74 μM
In vitro	Hematein (50 and 100 μM; 48 hours) inhibits CK2-specific Akt phosphorylation. Hematein (50 and 100 μM; 48 hours) causes apoptosis in A427 lung cancer cells. Hematein (10-100 μM; 14 days) inhibits cell growth in A427 lung cancer cells [1].
In vivo	In A427 lung cancer cell xenografts, Hematein (i.p.; 50 mg/kg; twice a week for 6 weeks) inhibits tumor growth [1].

Synonyms	Hydroxybrasilein
Molecular Weight	300.266
Formula	C16H12O6
CAS No.	475-25-2

Storage

store at low temperture

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Shirai, K., & Matsuoka, M. (1996). Structure and properties of hematein derivatives. Dyes and Pigments, 32(3), 159–169. 2. Hung MS, et al. Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograftmodel.Int J Oncol. 2013 Nov;43(5):1517-22.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Ovarian Cancer Compound Library Neuronal Differentiation Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Keywords

Hematein 475-25-2 Cytoskeletal Signaling PI3K/Akt/mTOR signaling Stem Cells Wnt/beta-catenin Akt Hydroxybrasilein Inhibitor inhibitor inhibit

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