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Cell Cycle/Checkpoint PLK HMN214

HMN214

Catalog No. T2438   CAS 173529-46-9
Synonyms: IVX-214

HMN-214(IVX214) is a potent PLK1 inhibitor with an average IC50 of 0.12 μM.

HMN214, CAS 173529-46-9
Pack Size Availability Price/USD Quantity
2 mg In stock 61.00
5 mg In stock 86.00
10 mg In stock 140.00
25 mg In stock 256.00
50 mg In stock 410.00
100 mg In stock 590.00
1 mL * 10 mM (in DMSO) In stock 94.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Preparing Solutions
Description HMN-214(IVX214) is a potent PLK1 inhibitor with an average IC50 of 0.12 μM.
Targets&IC50 PLK1,  
Cell Research
Cells are seeded into a 96-well microplate at a density of 3 × 103–1 × 104 cells/well. Dilutions of HMN-214 or HMN-176 are added the next day and the plate is incubated for 72 hours. The inhibition of growth is measured by the MTT assay and IC50 values are then obtained.(Only for Reference)
Cell lines: HeLa, PC-3, DU-145, MIAPaCa-2, U937, MCF-7, A549, and WiDr cells
Animal Research
Animal Model: BALB/c nude mice bearing xenografts of PC-3, A549, and WiDr cells
Synonyms IVX-214
Purity 100.00%
Molecular Weight 424.47
Formula C22H20N2O5S
CAS No. 173529-46-9

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 12 mg/mL (28.27 mM)

Ethanol: <1 mg/mL

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Solution 1

0.5% methylcellulose: 30 mg/mL

Citations

References and Literature
1. Takagi M, et al. Invest New Drugs, 2003, 21(4), 387-399. 2. Tanaka H, et al. Cancer Res, 2003, 63(20), 6942-6947. 3. DiMaio MA, et al. Mol Cancer Ther, 2009, 8(3), 592-601. 4. Christensen MD, et al. Kinome-level screening identifies inhibition of polo-like kinase-1 (PLK1) as a target for enhancing non-viral transgene expression. J Control Release. 2015 Apr 28;204:20-9.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Clinical Compound Library DNA Damage & Repair Compound Library Kinase Inhibitor Library Bioactive Lipid Compound Library Anti-cancer Clinical Compound Library Cell cycle related Compound Library

Related Products

Related compounds with same targets
ON-01910 Rigosertib TC-S 7005 Poloxime Poloxin 7-O-Prenylscopoletin ON-01910 HMN176

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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.