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HC-067047

Catalog No. T4680 CAS 883031-03-6

Synonyms: HC067047

HC-067047 is a potent and selective TRPV4 antagonist.Also inhibits the endogenous TRPV4-mediated response to 4α-PDH .

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

HC-067047, CAS 883031-03-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 30.00
5 mg	In stock	$ 62.00
10 mg	In stock	$ 98.00
25 mg	In stock	$ 198.00
50 mg	In stock	$ 328.00
100 mg	In stock	$ 528.00
1 mL * 10 mM (in DMSO)	In stock	$ 62.00

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Purity: 99.45%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	HC-067047 is a potent and selective TRPV4 antagonist.Also inhibits the endogenous TRPV4-mediated response to 4α-PDH .
Targets&IC50	TRPV4 (human):8 ± 6 nM, TRPV4 (rat):133 ± 25 nM, TRPV4 (mouse):17 ± 3 nM
In vivo	HC-067047 caused a significant reduction of the maximal micturition pressure in rats, which might be caused by an effect on TRPV4 in smooth muscle.

Synonyms	HC067047
Molecular Weight	471.51
Formula	C26H28F3N3O2
CAS No.	883031-03-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (53.02 mM)

References and Literature

1. Everaerts W et al. Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis.Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19084-9.

Citations

1. Li W, Xu Y, Liu Z, et al. TRPV4 inhibitor HC067047 produces antidepressant-like effect in LPS-induced depression mouse model. Neuropharmacology. 2021: 108834. 2. Dongming G, Xu Y, Wang Y, et al. Hyperactivation of TRPV4 causes the hippocampal pyroptosis pathway and results in cognitive impairment in LPS-treated mice. Behavioural Brain Research. 2022: 114223. 3. Deng Y, Li W, Niu L, et al. Amelioration of scopolamine-induced learning and memory impairment by the TRPV4 inhibitor HC067047 in ICR mice. Neuroscience Letters. 2022, 767: 136209. 4. Chen L, Mao M, Liu D, et al.HC067047 as a potent TRPV4 inhibitor repairs endotoxemia colonic injury.International Immunopharmacology.2023, 116: 109648. 5. Zhong X, Wang Y, Liu D, et al.HC067047 Ameliorates SAE by Suppressing Endoplasmic Reticulum Stress and Oxidative Stress-Induced Pyroptosis in the Hippocampi of Mice.Neuroscience.2023 6. Kong S, Chen T, Jia X, et al.Cell-specific NFIA upregulation promotes epileptogenesis by TRPV4-mediated astrocyte reactivity.Journal of Neuroinflammation.2023, 20(1): 1-22.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Ion Channel Inhibitor Library Anti-Cancer Compound Library Neuronal Signaling Compound Library NO PAINS Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

HC-067047 883031-03-6 Membrane transporter/Ion channel TRP/TRPV Channel Transient receptor potential channels Inhibitor HC 067047 HC067047 TRP Channel inhibit inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.