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Gusacitinib

Catalog No. T14331 CAS 1425381-60-7

Synonyms: ASN-002

Gusacitinib (ASN-002) (ASN-002) is spleen tyrosine kinase (SYK) and janus kinase (JAK) inhibitor (IC50: 5-46 nM).

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Gusacitinib, CAS 1425381-60-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 40.00
5 mg	In stock	$ 87.00
10 mg	In stock	$ 125.00
25 mg	In stock	$ 198.00
50 mg	In stock	$ 369.00
100 mg	In stock	$ 549.00
1 mL * 10 mM (in DMSO)	In stock	$ 118.00

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Purity: 99.58%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Gusacitinib (ASN-002) (ASN-002) is spleen tyrosine kinase (SYK) and janus kinase (JAK) inhibitor (IC50: 5-46 nM).
Targets&IC50	Syk/JAK:5-46 nM
In vitro	Gusacitinib (ASN-002) shows anti-proliferative activity in a broad panel of human cancer cell lines including DHL6, DHL4, OCI-LY10, H929, Pfeiffer, HT-1376, and Lovo, suggesting activity in both solid and hematological tumor types[1]. In mechanistic cell-based studies involving IgE and cytokine stimulations, Gusacitinib (ASN-002) strongly suppresses the SYK and JAK family kinase signaling pathways measured as pLAT and pSTAT levels, respectively.
In vivo	Gusacitinib (ASN-002) shows a favorable safety profile in rat and dog toxicology studies[1]. Gusacitinib (ASN-002) has good oral bioavailability, metabolic stability, is not a Pgp substrate, and shows little to no inhibition of CYP450 isozymes. In a multiple myeloma (H929) xenograft model, Gusacitinib (ASN-002) exhibits significant efficacy in inhibiting tumor growth (>95%) and it also significantly delays the onset of hind limb paralysis in the human erythroleukemia (HEL) mouse model.

Synonyms	ASN-002
Molecular Weight	460.53
Formula	C24H28N8O2
CAS No.	1425381-60-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/mL (206.28 mM), Sonification is recommended.

References and Literature

1. Sanjeeva Reddy, et al. Abstract 792: ASN002: A novel dual SYK/JAK inhibitor with strong antitumor activity. AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library Inhibitor Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Lung Cancer Compound Library Clinical Compound Library Anti-Liver Cancer Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

ZM39923 hydrochloride Ilginatinib Fedratinib Protosappanin A JAK-IN-33 JAK2-IN-9 Londamocitinib Icaritin

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Gusacitinib 1425381-60-7 Angiogenesis Chromatin/Epigenetic JAK/STAT signaling Stem Cells Tyrosine Kinase/Adaptors JAK Syk Janus kinase Spleen tyrosine kinase ASN002 ASN 002 Inhibitor inhibit ASN-002 inhibitor

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