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Gadodiamide Hydrate

Catalog No. T6508 CAS 122795-43-1

Synonyms: Omniscan

Gadodiamide Hydrate (Omniscan), a nonionic Gd3+ chelate, is frequently injected i.v. into magnetic resonance imaging (MRI) to enhance contrast.

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Gadodiamide Hydrate, CAS 122795-43-1

Pack Size	Availability	Price/USD
25 mg	5 days	$ 30.00
50 mg	5 days	$ 55.00
1 mL * 10 mM (in DMSO)	5 days	$ 68.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Gadodiamide Hydrate (Omniscan), a nonionic Gd3+ chelate, is frequently injected i.v. into magnetic resonance imaging (MRI) to enhance contrast.

In vivo

Gadodiamide results in half-life of 18, 38, and 75 minutes in rats, rabbits, and monkeys, respectively. Gadodiamide is shown to be excreted rapidly, primarily through the kidneys. [1] Gadodiamide, when administered i.v. as gadodiamide injection at a dosage of 0.3 mmol/kg, is stable in vivo and that the very major part of the dose (> 99%) is excreted in urine as an unchanged complex. [2] Gadodiamide produces focal and generalized myoclonus over several hours. Gadodiamide itself produces lesions in the central cerebellar regions resembling in character and severity those produced by the gadodiamide formulation, but not others. [3] Gadodiamide travels quickly throughout the ventricular system from the lateral ventricular site of injection to the fourth ventricle and foramina of Luschka and Magendie within 2 min. [4] Gadodiamide results in transient but statistically significant decreases in aortic pressure, left ventricular pressure, indices of left ventricular contractility and relaxation, and systemic and pulmonary vascular resistance, and increases in aortic blood flow in anesthetized dogs. Gadodiamide injection produces less severe alterations in hemodynamics than gadopentetate dimeglumine. [5]

Synonyms	Omniscan
Molecular Weight	591.67
Formula	C16H28GdN5O9C16H28GdN5O9·xH2O
CAS No.	122795-43-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 16 mg/mL (27.04 mM), Sonication and heating are recommended.

References and Literature

1. Harpur ES, et al. Invest Radiol, 1993, 28, S28-43. 2. Normann PT, et al. Eur J Drug Metab Pharmacokinet, 1995, 20(4), 307-313. 3. Ray DE, et al. AJNR Am J Neuroradiol, 1998, 19(8), 1455-1462. 4. Bui JD, et al. Neuroscience, 1999, 90(3), 1115-1122. 5. Peters JL, et al. Acta Radiol, 1993, 34(5), 510-516.

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Gadodiamide Hydrate 122795-43-1 Others Omniscan inhibit Gadodiamide Inhibitor inhibitor

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