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Fluoxetine

Name: Fluoxetine
Brand: TargetMol
SKU: T0450
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0450Cas No. 54910-89-3

Alias LY-110140

Fluoxetine (LY-110140) is a highly specific serotonin uptake inhibitor and selective 5-hydroxytryptamine (5-HT) reuptake inhibitor. Fluoxetine has antidepressant activity.

Fluoxetine

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Purity: 99.28%

Catalog No. T0450Alias LY-110140Cas No. 54910-89-3

Fluoxetine (LY-110140) is a highly specific serotonin uptake inhibitor and selective 5-hydroxytryptamine (5-HT) reuptake inhibitor. Fluoxetine has antidepressant activity.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$39	In Stock	In Stock
50 mg	$50	In Stock	In Stock
100 mg	$68	In Stock	In Stock
500 mg	$198	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.28%

Color:Transparent

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Product Introduction

Bioactivity

Description	Fluoxetine (LY-110140) is a highly specific serotonin uptake inhibitor and selective 5-hydroxytryptamine (5-HT) reuptake inhibitor. Fluoxetine has antidepressant activity.
Targets&IC50	HeLa cells:10 μM, HEK293 cells:1020 nM, MDA-MB-231 cells:0.5 μM, CHO cells:13.1 μM, Ventricular myocyte cells:2.82 μM, JAR cells:32.4 nM, MDA-MB-436 cells:0.5 μM
In vitro	METHODS: Mouse cortical near-pure neuronal cell cultures were treated with Fluoxetine (3-30 µM) for 24 h. Cell viability was measured by MTT assay. RESULTS: Fluoxetine induced neuronal death in a concentration-dependent manner. [1] METHODS: Human gastric cancer cells AGS were treated with Fluoxetine (10-20 µM) for 24 h. Apoptosis was detected by Flow cytometry. RESULTS: The number of early apoptotic cells in Fluoxetine-treated group was significantly increased by about 4-fold and 10-fold, respectively. [2]
In vivo	METHODS: To assay antidepressant activity in vivo, Fluoxetine (2.5-10 mg/kg) was administered intraperitoneally to MRL/MpJ mice twice daily for twenty-six days. RESULTS: Chronic treatment with 5 and 10 mg/kg Fluoxetine significantly increased cell proliferation and BDNF levels in the hippocampus. Only chronic treatment with the highest Fluoxetine increased BDNF levels in the frontal cortex. [3] METHODS: To test antidepressant activity in vivo, Fluoxetine (18 mg/kg) was administered orally once daily for three weeks to a model of corticosterone-induced anxiety/depression-like behavior in C57BL/6Ntac mice. RESULTS: Chronic Fluoxetine treatment reversed the anxiety phenotype. Regarding total distance traveled, chronic corticosterone treatment showed a nonsignificant trend that was eliminated by chronic Fluoxetine treatment. [4]
Synonyms	LY-110140

Chemical Properties

Molecular Weight	309.33
Formula	C₁₇H₁₈F₃NO
Cas No.	54910-89-3
Smiles	CNCCC(Oc1ccc(cc1)C(F)(F)F)c1ccccc1
Relative Density.	1.159 g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 237.5 mg/mL (767.79 mM), Sonication is recommended.

In Vivo Formulation

5% DMSO+95% Saline: 0.3 mg/mL (0.97 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2328 mL	16.1640 mL	32.3279 mL	161.6397 mL
5 mM	0.6466 mL	3.2328 mL	6.4656 mL	32.3279 mL
10 mM	0.3233 mL	1.6164 mL	3.2328 mL	16.1640 mL
20 mM	0.1616 mL	0.8082 mL	1.6164 mL	8.0820 mL
50 mM	0.0647 mL	0.3233 mL	0.6466 mL	3.2328 mL
100 mM	0.0323 mL	0.1616 mL	0.3233 mL	1.6164 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc