GPCR/G Protein 5-HT Receptor Fluoxetine


Catalog No. T0450   CAS 54910-89-3
Synonyms: LY-110140

Fluoxetine is the first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.

Fluoxetine, CAS 54910-89-3
Pack Size Availability Price/USD Quantity
10 mg In stock 38.00
25 mg In stock 50.00
50 mg In stock 64.00
100 mg In stock 83.00
200 mg In stock 149.00
500 mg In stock 250.00
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Purity 99.28%
Purity 99.65%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Fluoxetine is the first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
Targets&IC50 MRP1 ,   Sert (Sodium-dependent)
In vivo Fluoxetine treatment also reverses the deficit in escape latency observed in animals exposed to inescapable shock in adult male Sprague-Dawley rats[1]. Fluoxetine (5 mg/kg) alone increases cell proliferation in the dentate gyrus. Coadministration (fluoxetine 5 mg/kg + olanzapine) also significantly increases the number of BrdU-positive cells compared with the control group[2]. Fluoxetine combined with Olanzapine produces robust, sustained increases of extracellular levels of dopamine ([DA](ex)) and norepinephrine ([NE](ex)) up to 361% and 272% of the baseline, respectively, which are significantly greater than either drug alone[5].
Synonyms LY-110140
Purity 99.28%
Molecular Weight 309.33
Formula C17H18F3NO
CAS No. 54910-89-3


0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )


References and Literature
1. Malberg JE, et al. Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. Neuropsychopharmacology. 2003 Sep;28(9):1562-71. 2. Kodama M, et al. Chronic olanzapine or fluoxetine administration increases cell proliferation in hippocampus and prefrontal cortex of adult rat. Biol Psychiatry. 2004 Oct 15;56(8):570-80. 3. Wang JW, et al. Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells. J Neurosci. 2008 Feb 6;28(6):1374-84. 4. Bymaster FP, et al. Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Psychopharmacology (Berl). 2002 Apr;160(4):353-61. 5. Zhang W, et al. Synergistic effects of olanzapine and other antipsychotic agents in combination with fluoxetine on norepinephrine and dopamine release in rat prefrontal cortex. Neuropsychopharmacology. 2000 Sep;23(3):250-62. 6. Avitsur R1. Increased symptoms of illness following prenatal stress: Can it be prevented by fluoxetine Behav Brain Res. 2017 Jan 15;317:62-70. 7. Zhao J, Zhang Y, Liu Y, et al. Antidepressant-like effects of 1-methylnicotinamide in a chronic unpredictable mild stress model of depression[J]. Neuroscience Letters. 2020: 135535. 8. Liu L, Ji C H, Wang Y, et al. Antidepressant-like activity of L-701324 in mice: A behavioral and neurobiological characterization[J]. Behavioural Brain Research. 2020: 113038. 9. Jinyan Lv, Yemei Liang, Shiqing Zhang, Qunsheng Lan, Ziwei Xu, Xiaoyan Wu, Lijun Kang, Jing Ren, Ying Cao, Ting Wu, Kai Li Lin, Ken Kin Lam Yung, Xiong Cao, Jianxin Pang, and Pingzheng Zhou . DCPIB, an inhibitor of volume-regulated anion channels, distinctly modulates K2P channels [J]. ACS Chemical Neuroscience. 2019 Apr 17. 10. Jiang Bo, et al. Hippocampal Salt-Inducible Kinase 2 Plays a Role in Depression Via the CREB-Regulated Transcription Coactivator 1-Cyclic AMP Response Element Binding-Brain-Derived Neurotrophic Factor Pathway [J]. Biological psychiatry. 2019 Apr 15;85(8):650-666.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Anti-cancer Compound Library FDA-approved Drug Library GPCR Compound Library Fluorochemical Library Target-Focused Phenotypic Screening Library Anti-COVID-19 Compound Library FDA Approved & Pharmacopeial Drug Library

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