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Fluoxetine

Catalog No. T0450   CAS 54910-89-3
Synonyms: LY-110140

Fluoxetine (LY-110140) is a highly specific serotonin uptake inhibitor and selective 5-hydroxytryptamine (5-HT) reuptake inhibitor. Fluoxetine has antidepressant activity.

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Fluoxetine Chemical Structure
Fluoxetine, CAS 54910-89-3
Pack Size Availability Price/USD Quantity
10 mg In stock $ 30.00
25 mg In stock $ 41.00
50 mg In stock $ 57.00
100 mg In stock $ 74.00
200 mg In stock $ 123.00
500 mg In stock $ 225.00
1 mL * 10 mM (in DMSO) In stock $ 39.00
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Purity: 99.65%
Purity: 99.28%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Fluoxetine (LY-110140) is a highly specific serotonin uptake inhibitor and selective 5-hydroxytryptamine (5-HT) reuptake inhibitor. Fluoxetine has antidepressant activity.
In vitro METHODS: Mouse cortical near-pure neuronal cell cultures were treated with Fluoxetine (3-30 µM) for 24 h. Cell viability was measured by MTT assay.
RESULTS: Fluoxetine induced neuronal death in a concentration-dependent manner. [1]
METHODS: Human gastric cancer cells AGS were treated with Fluoxetine (10-20 µM) for 24 h. Apoptosis was detected by Flow cytometry.
RESULTS: The number of early apoptotic cells in Fluoxetine-treated group was significantly increased by about 4-fold and 10-fold, respectively. [2]
In vivo METHODS: To assay antidepressant activity in vivo, Fluoxetine (2.5-10 mg/kg) was administered intraperitoneally to MRL/MpJ mice twice daily for twenty-six days.
RESULTS: Chronic treatment with 5 and 10 mg/kg Fluoxetine significantly increased cell proliferation and BDNF levels in the hippocampus. Only chronic treatment with the highest Fluoxetine increased BDNF levels in the frontal cortex. [3]
METHODS: To test antidepressant activity in vivo, Fluoxetine (18 mg/kg) was administered orally once daily for three weeks to a model of corticosterone-induced anxiety/depression-like behavior in C57BL/6Ntac mice.
RESULTS: Chronic Fluoxetine treatment reversed the anxiety phenotype. Regarding total distance traveled, chronic corticosterone treatment showed a nonsignificant trend that was eliminated by chronic Fluoxetine treatment. [4]
Synonyms LY-110140
Molecular Weight 309.33
Formula C17H18F3NO
CAS No. 54910-89-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (32.33 mM)

TargetMolReferences and Literature

1. Hwang S, et al. Fluoxetine Induces Apoptotic and Oxidative Neuronal Death Associated with The Influx of Copper Ions in Cultured Neuronal Cells. Chonnam Med J. 2020 Jan;56(1):20-26. 2. Po WW, et al. Fluoxetine Simultaneously Induces Both Apoptosis and Autophagy in Human Gastric Adenocarcinoma Cells. Biomol Ther (Seoul). 2020 Mar 1;28(2):202-210. 3. Hodes GE, et al. Fluoxetine treatment induces dose dependent alterations in depression associated behavior and neural plasticity in female mice. Neurosci Lett. 2010 Oct 22;484(1):12-6. 4. Dulawa SC, et al. Effects of chronic fluoxetine in animal models of anxiety and depression. Neuropsychopharmacology. 2004 Jul;29(7):1321-30. 5. Zhang W, et al. Synergistic effects of olanzapine and other antipsychotic agents in combination with fluoxetine on norepinephrine and dopamine release in rat prefrontal cortex. Neuropsychopharmacology. 2000 Sep;23(3):250-62. 6. Avitsur R1. Increased symptoms of illness following prenatal stress: Can it be prevented by fluoxetine Behav Brain Res. 2017 Jan 15;317:62-70. 7. Zhao J, Zhang Y, Liu Y, et al. Antidepressant-like effects of 1-methylnicotinamide in a chronic unpredictable mild stress model of depression[J]. Neuroscience Letters. 2020: 135535. 8. Liu L, Ji C H, Wang Y, et al. Antidepressant-like activity of L-701324 in mice: A behavioral and neurobiological characterization[J]. Behavioural Brain Research. 2020: 113038. 9. Jinyan Lv, Yemei Liang, Shiqing Zhang, Qunsheng Lan, Ziwei Xu, Xiaoyan Wu, Lijun Kang, Jing Ren, Ying Cao, Ting Wu, Kai Li Lin, Ken Kin Lam Yung, Xiong Cao, Jianxin Pang, and Pingzheng Zhou . DCPIB, an inhibitor of volume-regulated anion channels, distinctly modulates K2P channels [J]. ACS Chemical Neuroscience. 2019 Apr 17. 10. Jiang Bo, et al. Hippocampal Salt-Inducible Kinase 2 Plays a Role in Depression Via the CREB-Regulated Transcription Coactivator 1-Cyclic AMP Response Element Binding-Brain-Derived Neurotrophic Factor Pathway [J]. Biological psychiatry. 2019 Apr 15;85(8):650-666.

TargetMolCitations

1. Jiang B, Wang H, Wang J L, et al. Hippocampal Salt-Inducible Kinase 2 Plays a Role in Depression Via the CREB-Regulated Transcription Coactivator 1-Cyclic AMP Response Element Binding-Brain-Derived Neurotrophic Factor Pathway. Biological Psychiatry. 2019, 85(8): 650-666 2. Persaud R, Li S C, Chao J D, et al. Clionamines stimulate autophagy, inhibit Mycobacterium tuberculosis survival in macrophages, and target Pik1. Cell Chemical Biology. 2021 3. Wu X, Lv J, Zhang S, et al. ML365 inhibits TWIK2 channel to block ATP-induced NLRP3 inflammasome. Acta Pharmacologica Sinica. 2021: 1-9. 4. Lv J, Liang Y, Zhang S, et al. DCPIB, an inhibitor of volume-regulated anion channels, distinctly modulates K2P channels. ACS Chemical Neuroscience. 2019, 10(6): 2786-2793 5. Liu Y, Tang W, Ji C, et al. The selective SIK2 inhibitor ARN-3236 produces strong antidepressant-like efficacy in mice via the hippocampal CRTC1-CREB-BDNF pathway. Frontiers in pharmacology. 2020, 11. 6. Liu L, Ji C H, Wang Y, et al. Antidepressant-like activity of L-701324 in mice: A behavioral and neurobiological characterization. Behavioural Brain Research. 2020: 113038. 7. Zhao J, Zhang Y, Liu Y, et al. Antidepressant-like effects of 1-methylnicotinamide in a chronic unpredictable mild stress model of depression. Neuroscience Letters. 2021 Jan 18;742:135535. doi: 10.1016 8. Zhang H, Xu H, Tang Q, et al. The selective serotonin reuptake inhibitors enhance the cytotoxicity of sorafenib in hepatocellular carcinoma cells. Anti-Cancer Drugs. 2021, 32(8): 793-801. 9. Ge J B, Jiang B, Shi T S, et al.Cucurbitacin B exerts significant antidepressant-like effects in a chronic unpredictable mild stress model of depression: Involvement of the hippocampal BDNF-TrkB system.International Journal of Neuropsychopharmacology.2023: pyad052.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Neurodegenerative Disease Compound Library Immunology/Inflammation Compound Library Pediatric Drug Library Bioactive Compound Library NO PAINS Compound Library FDA-Approved & Pharmacopeia Drug Library FDA-Approved Drug Library Drug Repurposing Compound Library

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Keywords

Fluoxetine 54910-89-3 Autophagy GPCR/G Protein Immunology/Inflammation Neuroscience MRP Serotonin Transporter 5-HT Receptor Inhibitor SERT LY 110140 inhibit 5-HTT SLC6A4 LY110140 LY-110140 inhibitor

 

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