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FR-167356

Catalog No. T27371 CAS 174185-16-1

Synonyms: FR167356, FR 167356

FR-167356 is a specific inhibitor of a3 isoform vacuolar type H⁺-ATPase with IC50s of 170 nM, 370 nM and 220 nM for osteoclast plasma membranes, renal brush border membranes and macrophage microsomes. FR-167356 reduces bone metastasis of B16-F10 cells.

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FR-167356, CAS 174185-16-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 329.00
5 mg	In stock	$ 798.00
10 mg	In stock	$ 1,090.00
25 mg	In stock	$ 1,650.00
50 mg	In stock	$ 2,230.00
100 mg	In stock	$ 2,930.00

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Purity: 99.19%

Purity: 98.44%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	FR-167356 is a specific inhibitor of a3 isoform vacuolar type H⁺-ATPase with IC50s of 170 nM, 370 nM and 220 nM for osteoclast plasma membranes, renal brush border membranes and macrophage microsomes. FR-167356 reduces bone metastasis of B16-F10 cells.
In vivo	In male C57BL/6 mice with B16-F10 xenografts, FR-167356 (200 mg/kg) reduces bone metastasis, inhibits tumor growth, and reduces the expression of MMP9[1].

Synonyms	FR167356, FR 167356
Molecular Weight	378.25
Formula	C19H17Cl2NO3
CAS No.	174185-16-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (7.08 mM)

References and Literature

1. Nishisho T, et al. The a3 isoform vacuolar type H⁺-ATPase promotes distant metastasis in the mouse B16 melanoma cells. Mol Cancer Res. 2011 Jul;9(7):845-55. 2. Morissette G, et al. Intracellular sequestration of amiodarone: role of vacuolar ATPase and macroautophagic transition of the resulting vacuolar cytopathology. Br J Pharmacol. 2009 Aug;157(8):1531-40. 3. Morissette G, Lodge R, Marceau F. Intense pseudotransport of a cationic drug mediated by vacuolar ATPase: procainamide-induced autophagic cell vacuolization. Toxicol Appl Pharmacol. 2008 May 1;228(3):364-77. 4. Niikura K, Takeshita N, Takano M. A vacuolar ATPase inhibitor, FR167356, prevents bone resorption in ovariectomized rats with high potency and specificity: potential for clinical application. J Bone Miner Res. 2005 Sep;20(9):1579-88. Epub 2005 May 31.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max Mitochondria-Targeted Compound Library

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Keywords

FR-167356 174185-16-1 Membrane transporter/Ion channel ATPase FR167356 FR 167356 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.