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Emtricitabine S-oxide

Catalog No. T11189 CAS 152128-77-3

Synonyms: Emtricitabine sulfoxide, Emtricitabine Degradant-III

Emtricitabine, a potent nucleoside reverse transcriptase inhibitor, is employed for managing HIV infection. Emtricitabine S-oxide, also known as Emtricitabine sulfoxide, represents a significant degradation byproduct of Emtricitabine.

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Emtricitabine S-oxide, CAS 152128-77-3

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Emtricitabine, a potent nucleoside reverse transcriptase inhibitor, is employed for managing HIV infection. Emtricitabine S-oxide, also known as Emtricitabine sulfoxide, represents a significant degradation byproduct of Emtricitabine.
In vitro	Emtricitabine degrades over 51%, 13% and 53% during acid, base and oxidative degradation respectively followed by formation of three major degradation products (Degradant-I to Degradant-III).Emtricitabine, an antiretroviral agent is used to evaluate degradation pathways under different stress conditions in order to identify degradation products as prescribed by ICH guidelines.

Synonyms	Emtricitabine sulfoxide, Emtricitabine Degradant-III
Molecular Weight	263.25
Formula	C8H10FN3O4S
CAS No.	152128-77-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. A Prakash, et al. Forced degradation study of emtricitabine for evaluation of genotoxic impurity in active pharmaceutical ingredient's (API) shelf life. World Journal of Pharmacy and Pharmaceutical Sciences (2015), 4(7), 1909-1919.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Emtricitabine S-oxide 152128-77-3 Microbiology/Virology Proteases/Proteasome Reverse Transcriptase HIV Protease Emtricitabine sulfoxide Emtricitabine Degradant-III Emtricitabine Soxide Emtricitabine S oxide Inhibitor inhibitor inhibit

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