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Emtricitabine

Catalog No. T6214 CAS 143491-57-0

Synonyms: FTC, Emtriva, BW1592

Emtricitabine (FTC) (FTC), a nucleoside reverse transcriptase inhibitor, exhibits inhibition activity against human immunodeficiency virus (HIV) and hepatitis B virus.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Emtricitabine, CAS 143491-57-0

Pack Size	Availability	Price/USD
50 mg	In stock	$ 45.00
100 mg	In stock	$ 68.00
500 mg	In stock	$ 113.00

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Purity: 100%

Purity: 99.93%

Purity: 99.91%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Emtricitabine (FTC) (FTC), a nucleoside reverse transcriptase inhibitor, exhibits inhibition activity against human immunodeficiency virus (HIV) and hepatitis B virus.
Targets&IC50	NRTI:0.01 µM(EC50)
In vivo	Reproductive and developmental toxicology studies conducted on emtricitabine show a favorable pre-clinical safety profile. When administered orally at doses up to 1000 mg/kg/day, pregnant animals experienced emtricitabine exposure levels (AUC0→24) approximately 60-fold (in mice) to 120-fold (in rabbits) higher than the human exposure at the recommended 200 mg daily dosage. Findings from a mouse fertility study indicate that emtricitabine does not impact fertility, sperm count, or early embryonic development. Additionally, there was no observed increase in malformations in mouse and rabbit embryofetal toxicology studies, nor did emtricitabine affect the development and fertility of the F1 progeny in a mouse pre- and post-natal study. These results underscore emtricitabine's lack of adverse effects on reproductive and developmental outcomes[6].
Cell Research	EA.hy926 cells were plated in a 12-, 24- or 96-well plates and grown in DMEM media supplemented with 3% FCS. Endothelial cells from PARP+/+and PARP-/- mice were isolated and cultured. Cell viability was determined by the reduction of yellow MTT into a purple formazan product by mitochondrial dehydrogenases of metabolically active cells. Following the treatment period, the experimental medium was removed and 100 μL MTT (1 mg/mL) added. After 1 h incubation, the MTT solution was carefully removed and the purple crystals were solubilized in 100 μL of DMSO. The DMSO was transferred to an ELISA plate and absorbance measured at 550 nm with a 620 nm[3].

Synonyms	FTC, Emtriva, BW1592
Molecular Weight	247.25
Formula	C8H10FN3O3S
CAS No.	143491-57-0

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (202.22 mM)

References and Literature

1. Venhoff N, et al. Antivir Ther, 2007, 12(7), 1075-1085. 2. Borroto-Esoda K, et al. Antivir Ther, 2006, 11(3), 377-384. 3. Richman DD, et al. Antivir Ther, 2001, 6(2), 83-88. 4. Saag MS, et al. Clin Infect Dis, 2006, 42(1), 126-131. 5. Hazen R, et al. J Acquir Immune Defic Syndr, 2003, 32(3), 255-258. 6. Xu P, et al. Combined Medication of Antiretroviral Drugs Tenofovir Disoproxil Fumarate, Emtricitabine, and Raltegravir Reduces Neural Progenitor Cell Proliferation In Vivo and In Vitro. J Neuroimmune Pharmacol. 2017 Dec;12(4):682-692. 7. Faltz M, et al. Effect of the Anti-retroviral Drugs Efavirenz, Tenofovir and Emtricitabine on Endothelial Cell Function: Role of PARP. Cardiovasc Toxicol. 2017 Jan 3. [Epub ahead of print]

Citations

1. Bao H, Yan J, Huang J, et al.Activation of endogenous retrovirus triggers microglial immuno-inflammation and contributes to negative emotional behaviors in mice with chronic stress.Journal of Neuroinflammation.2023, 20(1): 1-16.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library EMA Approved Drug Library Drug Repurposing Compound Library ReFRAME Related Library Immunology/Inflammation Compound Library Approved Drug Library Bioactive Compounds Library Max Nucleotide Compound Library CNS-Penetrant Compound Library Anti-Infection Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Emtricitabine 143491-57-0 Microbiology/Virology Proteases/Proteasome HIV Protease Reverse Transcriptase FTC Inhibitor Emtriva BW1592 HIV inhibit BW 1592 BW-1592 Human immunodeficiency virus inhibitor

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