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Oxidation-reduction Free radical scavengers Edaravone

Edaravone

Catalog No. T0407   CAS 89-25-8
Synonyms: MCI-186

Edaravone(MCI-186) is a potent new free radical scavenger used for the therapy of patients with acute brain infarction.

Edaravone, CAS 89-25-8
Pack Size Availability Price/USD Quantity
5 mg In stock 16.00
10 mg In stock 20.00
25 mg In stock 26.00
50 mg In stock 33.00
100 mg In stock 42.00
200 mg In stock 50.00
500 mg In stock 60.00
1 mL * 10 mM (in DMSO) In stock 54.00
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Purity 99.44%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Edaravone(MCI-186) is a potent new free radical scavenger used for the therapy of patients with acute brain infarction.
Targets&IC50 Free radical scavengers
Cell Research
Cell viability is quantified by MTT assay and trypan blue staining. MTT (5 mg/mL, 20 μL) is added to each well and incubated for 4 h at 37°C after the drug treatments. The medium is removed and the cell pellet is dissolved in DMSO. Then, the optical density (OD) values are measured at 570 nm using an ELISA reader.
Synonyms MCI-186
Purity 99.44%
Molecular Weight 174.2
Formula C10H10N2O
CAS No. 89-25-8

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 17.4 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Yoshida H, et al. CNS Drug Rev, 2006, 12(1), 9-20. 2. Zhang N, et al. Stroke, 2005, 36(10), 2220-2225. 3. Doi K, et al. Kidney Int, 2004, 65(5), 1714-1723. 4. Amemiya S, et al. Eur J Pharmacol, 2005, 516(2), 125-130. 6. Bai X, et al. Protective Effect of Edaravone on Glutamate-Induced Neurotoxicity in Spiral Ganglion Neurons. Neural Plast. 2016;2016:4034218. Epub 2016 Nov 10. 7. Wang F, Li R, Tu P, et al. Total glycosides of Cistanche deserticola promote neurological function recovery by inducing neurovascular regeneration via Nrf-2/Keap-1 pathway in MCAO/R rats[J]. Frontiers in Pharmacology. 2020, 11.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Clinical Compound Library Apoptosis Compound Library Oxidation-Reduction Compound Library FDA-approved Drug Library Anti-cancer Approved drug Library Anti-cancer Clinical Compound Library Anti-Metabolism Disease Compound Library Anti-Cardiovascular Disease Compound Library CNS-Penetrant Compound Library Anti-aging Compound Library Anti-cancer Drug library Drug Repurposing Library Neurodegenerative disease-related Compound Library Drug-induced Liver Injury (DILI) Compound Library NMPA-Approved Drug Library FDA Approved & Pharmacopeial Drug Library

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