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Edaravone

Edaravone
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Purity:100%
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Edaravone

Catalog No. T0407Cas No. 89-25-8
Edaravone (MCI-186)(MCI-186) is a potent new free radical scavenger used for the therapy of patients with acute brain infarction.
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Pack SizePrice/USDAvailabilityQuantity
500 mg$43In Stock
5 g$52In Stock
1 mL x 10 mM (in DMSO)$48In Stock
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Product Introduction

Bioactivity
Description
Edaravone (MCI-186)(MCI-186) is a potent new free radical scavenger used for the therapy of patients with acute brain infarction.
In vitro
Edaravone significantly improves neurological function in animals. Treatment with edaravone substantially reduces TUNEL-positive apoptotic cells and increases the expression of Bcl-2, while decreasing the immunoreactivity of Bax protein in the peri-infarct area. The research demonstrates that edaravone provides excellent protection against ischemic/reperfusion-induced brain injury through a Bcl-2/Bax protein-dependent anti-apoptotic mechanism. Following a 24-hour infusion of edaravone into murine brain tissue, there is a notable reduction in infarct volume and amelioration of neurological deficits. In the early stages post-reperfusion, edaravone significantly inhibits the accumulation of HNE-modified proteins and 8-OHdG in the penumbral region, reduces the expression of iNOS, diminishes microglial activation, and lowers the formation of nitrotyrosine. Edaravone also markedly attenuates renal function and pathological outcomes in rat kidneys, significantly reducing free radical production in renal tubular epithelial cells as indicated by fluorescence.
In vivo
Edaravone optimizes the state of NOS by reducing the detrimental isoforms iNOS and nNOS, while increasing the beneficial eNOS, thus favoring neuroprotection in ischemic stroke. It inhibits oxidation and enhances eNOS expression without boosting production, improving and preserving cerebral blood flow during reperfusion without necessitating peroxynitrite formation. Edaravone exerts its neuroprotective effect by mitigating neuronal damage from cerebral ischemia and inhibiting endothelial injury.
Cell Research
Cell viability is quantified by MTT assay and trypan blue staining. MTT (5?mg/mL, 20?μL) is added to each well and incubated for 4?h at 37°C after the drug treatments. The medium is removed and the cell pellet is dissolved in DMSO. Then, the optical density (OD) values are measured at 570?nm using an ELISA reader.
AliasMCI-186
Chemical Properties
Molecular Weight174.2
FormulaC10H10N2O
Cas No.89-25-8
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 45 mg/mL (258.32 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM5.7405 mL28.7026 mL57.4053 mL287.0264 mL
5 mM1.1481 mL5.7405 mL11.4811 mL57.4053 mL
10 mM0.5741 mL2.8703 mL5.7405 mL28.7026 mL
20 mM0.2870 mL1.4351 mL2.8703 mL14.3513 mL
50 mM0.1148 mL0.5741 mL1.1481 mL5.7405 mL
100 mM0.0574 mL0.2870 mL0.5741 mL2.8703 mL

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