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Edaravone

Catalog No. T0407   CAS 89-25-8
Synonyms: MCI-186

Edaravone (MCI-186)(MCI-186) is a potent new free radical scavenger used for the therapy of patients with acute brain infarction.

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Edaravone Chemical Structure
Edaravone, CAS 89-25-8
Pack Size Availability Price/USD Quantity
500 mg In stock $ 43.00
5 g In stock $ 52.00
1 mL * 10 mM (in DMSO) In stock $ 48.00
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Purity: 100%
Purity: 99.44%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Edaravone (MCI-186)(MCI-186) is a potent new free radical scavenger used for the therapy of patients with acute brain infarction.
Cell Research Cell viability is quantified by MTT assay and trypan blue staining. MTT (5?mg/mL, 20?μL) is added to each well and incubated for 4?h at 37°C after the drug treatments. The medium is removed and the cell pellet is dissolved in DMSO. Then, the optical density (OD) values are measured at 570?nm using an ELISA reader.
Synonyms MCI-186
Molecular Weight 174.2
Formula C10H10N2O
CAS No. 89-25-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 17.4 mg/mL (100 mM)

TargetMolReferences and Literature

1. Yoshida H, et al. CNS Drug Rev, 2006, 12(1), 9-20. 2. Zhang N, et al. Stroke, 2005, 36(10), 2220-2225. 3. Doi K, et al. Kidney Int, 2004, 65(5), 1714-1723. 4. Amemiya S, et al. Eur J Pharmacol, 2005, 516(2), 125-130. 6. Bai X, et al. Protective Effect of Edaravone on Glutamate-Induced Neurotoxicity in Spiral Ganglion Neurons. Neural Plast. 2016;2016:4034218. Epub 2016 Nov 10. 7. Wang F, Li R, Tu P, et al. Total glycosides of Cistanche deserticola promote neurological function recovery by inducing neurovascular regeneration via Nrf-2/Keap-1 pathway in MCAO/R rats[J]. Frontiers in Pharmacology. 2020, 11.

TargetMolCitations

1. Wang F, Li R, Tu P, et al. Total glycosides of Cistanche deserticola promote neurological function recovery by inducing neurovascular regeneration via Nrf-2/Keap-1 pathway in MCAO/R rats. Frontiers in Pharmacology. 2020, 11.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library High Solubility 3D Diversity Fragment Library NO PAINS Compound Library Anti-Cardiovascular Disease Compound Library Inhibitor Library Bioactive Compounds Library Max Angiogenesis related Compound Library

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Keywords

Edaravone 89-25-8 Apoptosis oxidation-reduction Proteases/Proteasome MMP Free radical scavengers Inhibitor Matrix metalloproteinases MCI 186 MCI-186 inhibit MCI186 inhibitor

 

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