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Edaravone

Catalog No. T0407 CAS 89-25-8

Synonyms: 依达拉奉, MCI-186

Edaravone(MCI-186) is a potent new free radical scavenger used for the therapy of patients with acute brain infarction.

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Edaravone, CAS 89-25-8

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Purity: 98%

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Storage & Solubility Information

Description	Edaravone(MCI-186) is a potent new free radical scavenger used for the therapy of patients with acute brain infarction.
Cell Research	Cell viability is quantified by MTT assay and trypan blue staining. MTT (5?mg/mL, 20?μL) is added to each well and incubated for 4?h at 37°C after the drug treatments. The medium is removed and the cell pellet is dissolved in DMSO. Then, the optical density (OD) values are measured at 570?nm using an ELISA reader.

Synonyms	依达拉奉, MCI-186
Molecular Weight	174.203
Formula	C10H10N2O
CAS No.	89-25-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 17.4 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Yoshida H, et al. CNS Drug Rev, 2006, 12(1), 9-20. 2. Zhang N, et al. Stroke, 2005, 36(10), 2220-2225. 3. Doi K, et al. Kidney Int, 2004, 65(5), 1714-1723. 4. Amemiya S, et al. Eur J Pharmacol, 2005, 516(2), 125-130. 6. Bai X, et al. Protective Effect of Edaravone on Glutamate-Induced Neurotoxicity in Spiral Ganglion Neurons. Neural Plast. 2016;2016:4034218. Epub 2016 Nov 10. 7. Wang F, Li R, Tu P, et al. Total glycosides of Cistanche deserticola promote neurological function recovery by inducing neurovascular regeneration via Nrf-2/Keap-1 pathway in MCAO/R rats[J]. Frontiers in Pharmacology. 2020, 11.

Citations

1. Wang F, Li R, Tu P, et al. Total glycosides of Cistanche deserticola promote neurological function recovery by inducing neurovascular regeneration via Nrf-2/Keap-1 pathway in MCAO/R rats. Frontiers in Pharmacology. 2020, 11.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Anti-Cardiovascular Disease Compound Library Inhibitor Library Drug-induced Liver Injury (DILI) Compound Library Oxidation-Reduction Compound Library Anti-Metabolism Disease Compound Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library FDA-Approved Drug Library Apoptosis Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Edaravone 89-25-8 蛋白酶体凋亡氧化还原 Apoptosis Free radical scavengers MMP MCI 186 Inhibitor Matrix metalloproteinases MCI-186 MCI186 inhibit inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.