Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ELX-02 sulfate, also known as NB-124 sulfate, is a novel compound currently under development as a therapeutic agent for genetic diseases triggered by nonsense mutations. This investigational compound, an advanced synthetic eukaryotic ribosome selective glycoside (ERSG), shows promising potential for targeted treatment.
Pack Size | Availability | Price/USD | Quantity |
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25 mg | Inquiry | $ 1,520.00 |
Description | ELX-02 sulfate, also known as NB-124 sulfate, is a novel compound currently under development as a therapeutic agent for genetic diseases triggered by nonsense mutations. This investigational compound, an advanced synthetic eukaryotic ribosome selective glycoside (ERSG), shows promising potential for targeted treatment. |
In vitro | ELX-02 (100-400 μg/mL) is not toxic, and permits read-through of nonsense mutations in human cells. |
In vivo | ELX-02 is rapidly eliminated from plasma in a biphasic manner with the terminal half-life (T1/2) of 0.5 h. ?In a CtnsY226X nonsense mutant mouse, subcutaneous ELX-02 accumulates in kidney tissue without overt renal toxicity and that ELX-02 (10 mg/kg X2/week for 3 weeks) reduces renal cystine accumulation in vivo.ELX-02 (10 and 30 mg/kg;?repeat subcutaneous administration;?twice weekly, total of 8 doses) shows accumulation in tissues that is dose dependent without gender difference.?In plasma ELX-02 is rapidly absorbed with a Tmax of 0.25 h after both single (a single subcutaneous injection at 10 mg/kg at dose volume of 5 mL/kg) and repeated administration (twice weekly with 10 mg/kg/dose for 21 days;?total of 7 administrations). |
Synonyms | NB-124 sulfate |
Molecular Weight | 580.6 |
Formula | C19H40N4O14S |
CAS No. | 1375073-94-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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ELX-02 sulfate 1375073-94-1 Others NB124 Sulfate NB-124 Sulfate ELX 02 sulfate ELX-02 Sulfate ELX 02 Sulfate NB-124 sulfate NB 124 Sulfate ELX02 Sulfate ELX02 sulfate inhibitor inhibit