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Disufenton sodium

Catalog No. T6201 CAS 168021-79-2

Synonyms: Cerovive, NXY059, OKN007, NXY-059, NXY 059

Disufenton sodium (NXY-059), a new-type nitrone, exhibits potently neuroprotective effects.

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Disufenton sodium, CAS 168021-79-2

Pack Size	Availability	Price/USD
5 mg	In stock	$ 37.00
10 mg	In stock	$ 60.00
25 mg	In stock	$ 118.00
50 mg	In stock	$ 217.00
100 mg	In stock	$ 397.00
200 mg	In stock	$ 582.00
500 mg	In stock	$ 913.00
1 mL * 10 mM (in DMSO)	In stock	$ 40.00

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Purity: 99%

Biological Description

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Description	Disufenton sodium (NXY-059), a new-type nitrone, exhibits potently neuroprotective effects.
In vitro	NXY-059 is more soluble than the spin trapping agent α-phenyl-N-tert-butyl nitrone (PBN). [1] In an in vitro blood-brain barrier (BBB) model, 250 mM of NXY-059 administered at the onset or up to 4 h after oxygen glucose deprivation (OGD) produces a significant reduction in the increased BBB permeability caused by OGD. Furthermore, OGD produces a huge influx of tissue plasminogen activator across the BBB, which is substantially reduced by NXY-059. [2]
In vivo	NXY-059 reduces infarct volume in rats subjected to 2 hours of middle cerebral artery occlusion in a dose-dependent manner. At equimolar doses (3.0 mg/kg for NXY-059 and 1.4 mg/kg for PBN), NXY-059 is more efficacious than PBN. Similar results are obtained when a recovery period of 7 days is allowed. The window of therapeutic opportunity for NXY-059 is 3 to 6 hours after the start of recirculation. [1] NXY-059, a free radical-trapping agent, has a substantial protective effect, lessening the disability caused by an experimentally induced stroke in a primate species. NXY-059 treatment reduces the overall amount of brain damage by >50% of saline-treatment values, with similar levels of protection afforded to both white and gray matter. [3] Treatment with NXY-059 (50 mg/kg subcutaneous plus 8.8 mg/kg/h for 3 days subcutaneous delivered via implanted osmotic pumps) significantly decreases neurological impairment following intracerebral hemorrhage in rat, and reduces the neutrophil infiltrate observed 48 hours post-hemorrhage in the vicinity of the hematoma, and the number of TUNEL-positive cells 48 hours post-hemorrhage at the hematoma margin. [4]

Synonyms	Cerovive, NXY059, OKN007, NXY-059, NXY 059
Molecular Weight	381.33
Formula	C11H13NNa2O7S2
CAS No.	168021-79-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 70 mg/mL (183.6 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 71 mg/mL (186.2 mM)

References and Literature

1. Kuroda S, et al, J Cereb Blood Flow Metab, 1999, 19(7), 778-787. 2. Culot M, et al, Brain Res, 2009, 19(1294), 144-152. 3. Marshall JW, et al, Stroke, 2001, 32(1), 190-198. 4. Peeling J, et al, Neuropharmacology, 2001, 40(3), 433-439.

Citations

1. Martínez-Alonso E, Escobar-Peso A, Aliena-Valero A, et al. Preclinical Characterization of Antioxidant Quinolyl Nitrone QN23 as a New Candidate for the Treatment of Ischemic Stroke. Antioxidants. 2022, 11(6): 1186

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Anti-Cancer Compound Library NO PAINS Compound Library Anti-Obesity Compound Library Anti-Ovarian Cancer Compound Library Metabolism Compound Library Preclinical Compound Library

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Keywords

Disufenton sodium 168021-79-2 Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species Inhibitor Cerovive OKN-007 OKN 007 inhibit NXY059 Disufenton OKN007 NXY-059 NXY 059 inhibitor

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