Shopping Cart

Your shopping cart is currently empty

Diclofensine hydrochloride

Name: Diclofensine hydrochloride
Brand: TargetMol
SKU: T7745
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T7745Cas No. 34041-84-4

Alias Ro 8-4650 hydrochloride

Diclofensine hydrochloride (Ro 8-4650 hydrochloride) is a Novel Antidepressant, on Peripheral Adrenergic Function

Diclofensine hydrochloride

Copy Product Info

😃Good

Purity: 99.93%

Catalog No. T7745Alias Ro 8-4650 hydrochlorideCas No. 34041-84-4

Diclofensine hydrochloride (Ro 8-4650 hydrochloride) is a Novel Antidepressant, on Peripheral Adrenergic Function

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$47	In Stock	In Stock
10 mg	$77	In Stock	In Stock
25 mg	$155	In Stock	In Stock
50 mg	$297	In Stock	In Stock
100 mg	$428	In Stock	In Stock
200 mg	$598	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.93%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Diclofensine hydrochloride (Ro 8-4650 hydrochloride) is a Novel Antidepressant, on Peripheral Adrenergic Function
In vitro	The action of diclofensine on peripheral neuronal adrenergic function was studied through tests of the blood pressure response to NE, tyramine, and phenylephrine (PE).?The blood pressure response to NE was enhanced and that to tyramine was decreased by diclofensine, as a result of its inhibitive action on peripheral neuronal amine uptake.?PE sensitivity was also enhanced by diclofensine as well as after a single dose of desmethylimipramine (DMI).?In contrast to the common opinion that PE does not interact with the neuronal uptake mechanism, the increase in PE-induced blood pressure response after diclofensine and DMI suggests that PE, a nonbiogenic amine, does indeed enter into the peripheral adrenergic neuron[1].
Synonyms	Ro 8-4650 hydrochloride

Chemical Properties

Molecular Weight	358.69
Formula	C₁₇H₁₈Cl₃NO
Cas No.	34041-84-4
Smiles	Cl.COc1ccc2C(CN(C)Cc2c1)c1ccc(Cl)c(Cl)c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 52 mg/mL (144.97 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.7879 mL	13.9396 mL	27.8792 mL	139.3961 mL
5 mM	0.5576 mL	2.7879 mL	5.5758 mL	27.8792 mL
10 mM	0.2788 mL	1.3940 mL	2.7879 mL	13.9396 mL
20 mM	0.1394 mL	0.6970 mL	1.3940 mL	6.9698 mL
50 mM	0.0558 mL	0.2788 mL	0.5576 mL	2.7879 mL
100 mM	0.0279 mL	0.1394 mL	0.2788 mL	1.3940 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc