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Dehydroaltenusin

Dehydroaltenusin
Dehydroaltenusin is a selective eukaryotic DNA polymerase α inhibitor and a type of antibiotic produced by a fungus (IC50: 0.68 μM). Dehydroaltenusin inhibits mammalian pol α activity.
Catalog No. T15094Cas No. 31186-13-7
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Dehydroaltenusin

Catalog No. T15094Cas No. 31186-13-7
Dehydroaltenusin is a selective eukaryotic DNA polymerase α inhibitor and a type of antibiotic produced by a fungus (IC50: 0.68 μM). Dehydroaltenusin inhibits mammalian pol α activity.
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Product Introduction

Bioactivity
Description
Dehydroaltenusin is a selective eukaryotic DNA polymerase α inhibitor and a type of antibiotic produced by a fungus (IC50: 0.68 μM). Dehydroaltenusin inhibits mammalian pol α activity.
Targets&IC50
DNA polymerase α:0.68 μM
In vitro
Dehydroaltenusin (38.0 μM; 6 hours) inhibits cell growth by blocking the S-phase of DNA replication. Dehydroaltenusin (38.0-44.4 μM; 24 hours) inhibits cell growth in a dose-dependent manner (LD50s: 38.0 to 44.4 μM). Dehydroaltenusin (75.0 μM; 24 hours) has a potent apoptotic effect on human cancer cells, DNA ladders can be detected after 12 h of incubation with dehydroaltenusin.
In vivo
Dehydroaltenusin possesses anti-tumor activity against human adenocarcinoma tumors in vivo. Dehydroaltenusin (injection; 20 mg/kg; 2-day intervals; 12-39 days) shows suppressed tumor growth from 21 days.
Chemical Properties
Molecular Weight288.255
FormulaC15H12O6
Cas No.31186-13-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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