Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dalfopristin (mesylate) is a streptogramin antibiotic and a 50S ribosome inhibitor. Streptogramins are produced by a variety of Streptomyces sp as a mixture (ratio of 7:3) of two chemically unrelated compounds, type A and B. Dalfopristin, the type A Streptogramin is often combined with type B streptogramin antibiotic, quinupristin, to produce Quinupristin-Dalfopristin Complex, known commercially as Synercid. The ribosome is composed of two ribonucleoprotein subunits, the 50S, and 30S. The 50S ribosome inhibitors inhibited protein synthesis.
Pack Size | Availability | Price/USD | Quantity |
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1 mg | Inquiry | $ 477.00 | |
5 mg | Inquiry | $ 1,550.00 |
Description | Dalfopristin (mesylate) is a streptogramin antibiotic and a 50S ribosome inhibitor. Streptogramins are produced by a variety of Streptomyces sp as a mixture (ratio of 7:3) of two chemically unrelated compounds, type A and B. Dalfopristin, the type A Streptogramin is often combined with type B streptogramin antibiotic, quinupristin, to produce Quinupristin-Dalfopristin Complex, known commercially as Synercid. The ribosome is composed of two ribonucleoprotein subunits, the 50S, and 30S. The 50S ribosome inhibitors inhibited protein synthesis. |
In vitro | Dalfopristin is a cyclic polyunsaturated macrolactone that interferes with the binding of tRNA substrates to both A- and P-sites [2]. Dalfopristin blocked the access of peptidyl-tRNAs to the ribosome and peptidyltransferase elongation reaction in bacteria [1]. quinupristin and dalfopristin acted synergistically to kill Gram-positive bacteria, as well as some Gram-negative and anaerobic bacteria [2][3]. Dalfopristin hydrolyzed rapidly to virginiamycin M under physiological conditions. |
Synonyms | Dalfopristin (mesylate) |
Molecular Weight | 787 |
Formula | C34H51N4O9S·CH3SO3 |
CAS No. | T22707 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: Soluble
DMSO: Soluble
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Dalfopristin (mesylate) (112362-50-2 free base) T22707 Others Dalfopristin (mesylate) Dalfopristin 112362-50-2 free base Dalfopristin (mesylate) (112362502 free base) Dalfopristin (mesylate) (112362 50 2 free base) 112362-50-2 inhibitor inhibit