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Dabigatran

Dabigatran
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Purity:98.65%
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Dabigatran

Catalog No. T6295Cas No. 211914-51-1
Dabigatran (BIBR 953ZW) is a THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the risk of stroke and systemic EMBOLISM in patients with nonvalvular atrial fibrillation.
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Pack SizePrice/USDAvailabilityQuantity
1 mg$36In Stock
2 mg$52In Stock
5 mg$85In Stock
10 mg$143In Stock
25 mg$283In Stock
50 mg$477In Stock
100 mg$698In Stock
500 mg$1,470In Stock
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Product Introduction

Bioactivity
Description
Dabigatran (BIBR 953ZW) is a THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the risk of stroke and systemic EMBOLISM in patients with nonvalvular atrial fibrillation.
In vitro
BIBR 953 is a very potent anticoagulant. BIBR 953 shows that the terminal phenyl can be substituted by the more hydrophilic 2-pyridyl group without substantial loss of activity. BIBR 953 inhibits thrombin, plasmin, factor Xa, trypsin, tPA and activated protein C with Ki of 4.5 nM, 1.7 μM, 3.8 μM, 50 nM, 45 μM and 20 μM, respectively. [1] BIBR 953 specifically and reversibly inhibits thrombin. [2]
In vivo
BIBR 953 exhibits the most favorable activity profile following i.v. administration to rats. [1] The bioavailability of dabigatran after p.o. administration of dabigatran etexilate is 7.2%. Dabigatran is predominantly excreted in the feces after p.o. treatment and in the urine after i.v. treatment. The mean terminal half-life of dabigatran is approximately 8 hours. Dabigatran acylglucuronides accounts for 0.4% and 4% of the dose in urine after p.o. and i.v. dosing, respectively. [3]
AliasBIBR 953, BIBR 953ZW
Chemical Properties
Molecular Weight471.51
FormulaC25H25N7O3
Cas No.211914-51-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
0.1 M HCL: 12.5 mg/mL (26.51 mM)
DMSO: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 0.1 mg/mL (insoluble)
Solution Preparation Table
0.1 M HCL
1mg5mg10mg50mg
50 mM0.0424 mL0.2121 mL0.4242 mL2.1208 mL
100 mM0.0212 mL0.1060 mL0.2121 mL1.0604 mL

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