Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Dabigatran is a THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the risk of stroke and systemic EMBOLISM in patients with nonvalvular atrial fibrillation.
Description | Dabigatran is a THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the risk of stroke and systemic EMBOLISM in patients with nonvalvular atrial fibrillation. |
Targets&IC50 | Thrombin:9.3 nM |
In vitro | BIBR 953 is a very potent anticoagulant. BIBR 953 shows that the terminal phenyl can be substituted by the more hydrophilic 2-pyridyl group without substantial loss of activity. BIBR 953 inhibits thrombin, plasmin, factor Xa, trypsin, tPA and activated protein C with Ki of 4.5 nM, 1.7 μM, 3.8 μM, 50 nM, 45 μM and 20 μM, respectively. [1] BIBR 953 specifically and reversibly inhibits thrombin. [2] |
In vivo | BIBR 953 exhibits the most favorable activity profile following i.v. administration to rats. [1] The bioavailability of dabigatran after p.o. administration of dabigatran etexilate is 7.2%. Dabigatran is predominantly excreted in the feces after p.o. treatment and in the urine after i.v. treatment. The mean terminal half-life of dabigatran is approximately 8 hours. Dabigatran acylglucuronides accounts for 0.4% and 4% of the dose in urine after p.o. and i.v. dosing, respectively. [3] |
Synonyms | BIBR 953ZW, 达比加群, BIBR 953 |
Molecular Weight | 471.521 |
Formula | C25H25N7O3 |
CAS No. | 211914-51-1 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
0.1 M HCL: 12.5 mg/mL (26.51 mM), Need ultrasonic
DMSO: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 0.1 mg/mL (insoluble)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Dabigatran 211914-51-1 蛋白酶体 Thrombin Inhibitor BIBR-953 inhibit BIBR 953 BIBR 953ZW BIBR953 inhibitor