DTP3

DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.

Catalog No. T22319Cas No. 1809784-29-9

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DTP3

Catalog No. T22319Cas No. 1809784-29-9

DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.

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Pack Size	Price	Availability
2 mg	$76	5 days
5 mg	$128	5 days
10 mg	$228	5 days

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Product Introduction

Bioactivity

Description	DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.
In vitro	DTP3 physically interacts with MKK7 in isolation and within the complex with GADD45β, and dissociates the GADD45β/MKK7 complex via an allosteric mechanism. DTP3 selectively kills cells and induces apoptosis in MM cells with functional MKK7 and elevated GADD45β expression without toxicity to normal cells. In addition, DTP3 displays synergistic activity with bortezomib in two different MM cell lines, exhibiting a combination index of 0.56 in KMS-12 cells and of 0.21 in U266 cells. [1]
In vivo	DTP3 treatment with 14.5 mg/kg/day exhibits potent antitumor activity against MM in mouse plasmacytoma model. [1]

Chemical Properties

Molecular Weight	525.6
Formula	C₂₆H₃₅N₇O₅
Cas No.	1809784-29-9

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

Ethanol: 100 mg/ml (190.26 mM)

H2O: 100 mg/ml (190.26 mM)

DMSO: 100 mg/ml (190.26 mM)

Solution Preparation Table

Ethanol/H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9026 mL	9.5129 mL	19.0259 mL	95.1294 mL
5 mM	0.3805 mL	1.9026 mL	3.8052 mL	19.0259 mL
10 mM	0.1903 mL	0.9513 mL	1.9026 mL	9.5129 mL
20 mM	0.0951 mL	0.4756 mL	0.9513 mL	4.7565 mL
50 mM	0.0381 mL	0.1903 mL	0.3805 mL	1.9026 mL
100 mM	0.0190 mL	0.0951 mL	0.1903 mL	0.9513 mL

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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