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DTP3

DTP3
DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.
Catalog No. T22319Cas No. 1809784-29-9
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DTP3

Catalog No. T22319Cas No. 1809784-29-9
DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
2 mg$765 days
5 mg$1285 days
10 mg$2285 days
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Product Introduction

Bioactivity
Description
DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.
In vitro
DTP3 physically interacts with MKK7 in isolation and within the complex with GADD45β, and dissociates the GADD45β/MKK7 complex via an allosteric mechanism. DTP3 selectively kills cells and induces apoptosis in MM cells with functional MKK7 and elevated GADD45β expression without toxicity to normal cells. In addition, DTP3 displays synergistic activity with bortezomib in two different MM cell lines, exhibiting a combination index of 0.56 in KMS-12 cells and of 0.21 in U266 cells. [1]
In vivo
DTP3 treatment with 14.5 mg/kg/day exhibits potent antitumor activity against MM in mouse plasmacytoma model. [1]
Chemical Properties
Molecular Weight525.6
FormulaC26H35N7O5
Cas No.1809784-29-9
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 100 mg/ml (190.26 mM)
H2O: 100 mg/ml (190.26 mM)
DMSO: 100 mg/ml (190.26 mM)
Solution Preparation Table
Ethanol/H2O/DMSO
1mg5mg10mg50mg
1 mM1.9026 mL9.5129 mL19.0259 mL95.1294 mL
5 mM0.3805 mL1.9026 mL3.8052 mL19.0259 mL
10 mM0.1903 mL0.9513 mL1.9026 mL9.5129 mL
20 mM0.0951 mL0.4756 mL0.9513 mL4.7565 mL
50 mM0.0381 mL0.1903 mL0.3805 mL1.9026 mL
100 mM0.0190 mL0.0951 mL0.1903 mL0.9513 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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