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DDP-38003 dihydrochloride

Catalog No. T10983L CAS 1831167-98-6

DDP-38003 dihydrochloride is an orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor (IC50: 84 nM).

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DDP-38003 dihydrochloride Chemical Structure

DDP-38003 dihydrochloride, CAS 1831167-98-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 77.00
5 mg	In stock	$ 163.00
10 mg	In stock	$ 297.00
25 mg	In stock	$ 567.00
50 mg	In stock	Inquiry
1 mL * 10 mM (in DMSO)	In stock	$ 236.00

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Purity: 99.5%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	DDP-38003 dihydrochloride is an orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor (IC50: 84 nM).
Targets&IC50	KDM1A/LSD1:84 nM
In vitro	DDP-38003 is more active in reducing the colony forming ability and in inducing thedifferentiation of THP-1 cells compared to the 1R, 2S analogue. DDP-38003 inhibits KDM1A (IC50: 84 nM) [1].
In vivo	DDP-38003, an oral anticancer candidate, possesses a half-life of 8 hours and demonstrates in vivo efficacy, resulting in a 62% survival increase in mouse leukemia models through KDM1A inhibition. The treatment's efficacy is dose-dependent, with survival rates augmenting by 35% and 62% at doses of 11.25 mg/kg and 22.50 mg/kg, respectively[1].

Molecular Weight	423.38
Formula	C21H28Cl2N4O
CAS No.	1831167-98-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27mg/mL (63.8mM)

References and Literature

1. Vianello P, et al. Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent. J Med Chem. 2016 Feb 25;59(4):1501-17.

Related compound libraries

This product is contained In the following compound libraries：

Epigenetics Compound Library Histone Modification Compound Library

Related Products

Related compounds with same targets

Acetyl Pentapeptide-1 acetate KDM4C-IN-1 GSK2879552 LSD1-IN-27 Kgp-IN-1 JMJD7-IN-1 (rel)-Tranylcypromine D5 hydrochloride Procaine

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

DDP-38003 dihydrochloride 1831167-98-6 Chromatin/Epigenetic Histone Demethylase DDP-38003 DDP 38003 Dihydrochloride DDP-38003 Dihydrochloride DDP 38003 dihydrochloride DDP 38003 DDP38003 dihydrochloride DDP38003 DDP38003 Dihydrochloride inhibitor inhibit

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