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Cytembena

Catalog No. T27112 CAS 21739-91-3

Cytembena is a cytostatic and a carcinogenic compound that may increase the incidence of fibroadenomas.Cytembena broadly inhibits DNA biosynthesis.

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Cytembena, CAS 21739-91-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 85.00
5 mg	In stock	$ 210.00
10 mg	In stock	$ 310.00
25 mg	In stock	$ 586.00
50 mg	In stock	$ 780.00
100 mg	In stock	$ 1,090.00
500 mg	In stock	$ 2,180.00

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Purity: 99.53%

Biological Description

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Description

Cytembena is a cytostatic and a carcinogenic compound that may increase the incidence of fibroadenomas.Cytembena broadly inhibits DNA biosynthesis.

In vivo

Cytembena was given i.p. in doses of 5, 10, 20, 40, and 80 mg/kg body wt. to Wistar rats and in doses of 20, 40, and 80 mg/kg body wt. to ICR mice and to Chinese hamsters. Five patients with various types of malignancy, so far medically untreated, received 20 mg Cytembena/kg body wt i.v. A combination of Cytembena and cyclophosphamide was applied i.p. in single equal doses 1: 1 of 5,10, 20, and 40 mg/kg body wt to ICR mice, Chinese hamsters, and Wistar rats. Patients were given i.v. 20 mg Cytembena and 20 mg cyclophosphamide/kg body wt. Bone marrow cells were examined 24 h after the administration. The frequency of abnormal metaphases and chromosomal breaks after Cytembena treatment was low; nonetheless, the indicated dose-effect relationship was found in all the rodents used. The frequency of chromosomal breaks was 2-3 times higher in rodents in comparison with men, after treatment with a dose of 20 mg Cytembena/kg body wt. The highest frequencies of induced aberrations were found in mice. The rodents appeared to be 3--4 times more sensitive to the induction of chromosomal breaks and abnormal metaphases than men, after a dose of 20 mg Cytembena and 20 mg cyclophosphamide/kg body wt.[1]

Molecular Weight	307.07
Formula	C11H8BrNaO4
CAS No.	21739-91-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Goetz P, et al. Relationship between experimental results in mammals and man. II. Cytogenetic analysis of bone-marrow cells after treatment of cytembena and cyclophosphamide- cytembena combination. Mutat Res. 1976 Nov 1;41(1 spel. no):143-52. 2. Schück O, et al. Pharmacokinetics of Cytembena in chronic renal impairment. Neoplasma. 1976;23(2):161-70. 3. Jackson RC, et al. The reaction of Cytembena with cellular thiol compounds. Neoplasma. 1976;23(4):355-62. 4. Falkson HC, et al. Phase II trial of cytembena in patients with advanced ovarian and breast cancer. Cancer Treat Rep. 1976 Nov;60(11):1655-8.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Keywords

Cytembena 21739-91-3 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis inhibitor inhibit

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