Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cyclotriazadisulfonamide hydrochloride is a selective inhibitor of CD4-targeted HIV entry and inhibits the co-translational translocation of human CD4 into the ER lumen in a signal peptide-dependent way.
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Description | Cyclotriazadisulfonamide hydrochloride is a selective inhibitor of CD4-targeted HIV entry and inhibits the co-translational translocation of human CD4 into the ER lumen in a signal peptide-dependent way. |
In vitro | Cyclotriazadisulfonamide hydrochloride exhibits an EC50 of 0.4 μg/mL for CD4 in MO-DC cells. Cyclotriazadisulfonamide hydrochloride (10 μg/mL) results in 83% downregulation of cell surface CD4. Cyclotriazadisulfonamide hydrochloride prevents MT-4 cells from HIV-1 and SIV infection with EC50s of 0.7 and 1.2 g/ml, respectively. Cyclotriazadisulfonamide hydrochloride significantly decreases the amount of cell surface CD4 -the main receptor for HIV -without altering the expression of any other cellular receptor examined so far[1]. |
Synonyms | Cyclotriazadisulfonamide hydrochloride (182316-44-5 Free base) |
Molecular Weight | 618.25 |
Formula | C31H40ClN3O4S2 |
CAS No. | 392287-03-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Cyclotriazadisulfonamide hydrochloride 392287-03-5 Microbiology/Virology Proteases/Proteasome HIV Protease Cyclotriazadisulfonamide hydrochloride (182316-44-5 Free base) 182316-44-5 182316-44-5 Free base Cyclotriazadisulfonamide Hydrochloride inhibitor inhibit