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Crinecerfont

Catalog No. T31095 CAS 752253-39-7

Synonyms: SSR125543, SSR 125543, SSR-125543, SSR125543A, SSR 125543A, SSR-125543A

Crinecerfont (SSR-125543) is a selective antagonist of corticotropin-releasing factor 1 receptor (CRF1) and can be used in studies about Classic congenital adrenal hyperplasia.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Crinecerfont, CAS 752253-39-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 195.00
2 mg	In stock	$ 293.00
5 mg	In stock	$ 449.00
10 mg	In stock	$ 659.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,390.00
100 mg	In stock	$ 1,880.00
500 mg	In stock	$ 3,780.00

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Purity: 99.10%

Purity: 98.01%

ee: 98.98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Crinecerfont (SSR-125543) is a selective antagonist of corticotropin-releasing factor 1 receptor (CRF1) and can be used in studies about Classic congenital adrenal hyperplasia.

Synonyms	SSR125543, SSR 125543, SSR-125543, SSR125543A, SSR 125543A, SSR-125543A
Molecular Weight	483.04
Formula	C27H28ClFN2OS
CAS No.	752253-39-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

References and Literature

1. Philbert J, et al. The CRF₁ receptor antagonist SSR125543 prevents stress-induced long-lasting sleep disturbances in a mouse model of PTSD: comparison with paroxetine and d-cycloserine. Behav Brain Res. 2015 Feb 15;279:41-6. 2. Ramos Ade T, et al. Drug-induced suppression of ACTH secretion does not promote anti-depressive or anxiolytic effects. Behav Brain Res. 2014 May 15;265:69-75. 3. Douma TN, et al. CRF1 receptor antagonists do not reverse pharmacological disruption of prepulse inhibition in rodents. Psychopharmacology (Berl). 2014 Apr;231(7):1289-303. 4. Auchus RJ, et al. Crinecerfont Lowers Elevated Hormone Markers in Adults With 21-Hydroxylase Deficiency Congenital Adrenal Hyperplasia. J Clin Endocrinol Metab. 2022 Feb 17;107(3):801-812.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library GPCR Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Bioactive Compound Library ReFRAME Related Library Bioactive Compounds Library Max Clinical Compound Library

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Keywords

Crinecerfont 752253-39-7 GPCR/G Protein CRFR SSR125543 SSR 125543 SSR-125543 SSR125543A SSR 125543A SSR-125543A inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.