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Clorobiocin

Catalog No. T25265 CAS 39868-96-7

Synonyms: RP18631, RP 18631, RP-18631

Clorobiocin is an aminocoumarin antibacterial that suppresses the enzyme DNA gyrase.

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Clorobiocin, CAS 39868-96-7

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5 mg	Inquiry	$ 3,368.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Clorobiocin is an aminocoumarin antibacterial that suppresses the enzyme DNA gyrase.

Synonyms	RP18631, RP 18631, RP-18631
Molecular Weight	697.13
Formula	C35H37ClN2O11
CAS No.	39868-96-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Rückert C, Kalinowski J, Heide L, Apel AK. Draft Genome Sequence of Streptomyces roseochromogenes subsp. oscitans DS 12.976, Producer of the Aminocoumarin Antibiotic Clorobiocin. Genome Announc. 2014 Jan 9;2(1). pii: e01147-13. doi: 10.1128/genomeA.01147-13. PubMed PMID: 24407645; PubMed Central PMCID: PMC3886958. 2. Flinspach K, Westrich L, Kaysser L, Siebenberg S, Gomez-Escribano JP, Bibb M, Gust B, Heide L. Heterologous expression of the biosynthetic gene clusters of coumermycin A(1), clorobiocin and caprazamycins in genetically modified Streptomyces coelicolor strains. Biopolymers. 2010 Sep;93(9):823-32. doi: 10.1002/bip.21493. PubMed PMID: 20578003. 3. Eustáquio AS, Gust B, Luft T, Li SM, Chater KF, Heide L. Clorobiocin biosynthesis in Streptomyces: identification of the halogenase and generation of structural analogs. Chem Biol. 2003 Mar;10(3):279-88. PubMed PMID: 12670542. 4. Freitag A, Wemakor E, Li SM, Heide L. Acyl transfer in clorobiocin biosynthesis: involvement of several proteins in the transfer of the pyrrole-2-carboxyl moiety to the deoxysugar. Chembiochem. 2005 Dec;6(12):2316-25. PubMed PMID: 16276503.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Clorobiocin 39868-96-7 RP18631 RP 18631 RP-18631 inhibitor inhibit

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