Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cloperastine fendizoate (Hustazol) inhibits the hERG K+ currents in a concentration-dependent manner (IC50: 27 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
500 mg | In stock | $ 42.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 46.00 |
Description | Cloperastine fendizoate (Hustazol) inhibits the hERG K+ currents in a concentration-dependent manner (IC50: 27 nM). |
Targets&IC50 | K+ current:27 nM |
In vitro | Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects [2]. |
In vivo | In anesthetized guinea pigs, a therapeutic dose (1 mg/kg) of Cloperastine extended the QT interval and monophasic action potential duration, without altering the PR interval or QRS width [1]. When administered intraperitoneally, Cloperastine hydrochloride exhibits relatively low acute toxicity in rats and mice. As Cloperastine fendizoate, its oral administration demonstrates minimal toxicity, with LD50 values exceeding 1000 and 2000 mg/kg in rats and mice, respectively [2]. |
Synonyms | Hustazol |
Molecular Weight | 648.19 |
Formula | C40H38ClNO5 |
CAS No. | 85187-37-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 9.0 mg/mL (13.9 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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