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Cirsiliol

Catalog No. T10821 CAS 34334-69-5

Cirsiliol is a selective inhibitor of 5-lipoxygenase and a competitive low-affinity ligand of benzodiazepine receptors.

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Cirsiliol, CAS 34334-69-5

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Purity: 98%

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Description	Cirsiliol is a selective inhibitor of 5-lipoxygenase and a competitive low-affinity ligand of benzodiazepine receptors.
In vitro	Cirsiliol (0.01 to 300 μM) causes concentration-dependent relaxation of rat isolated ileum. Cirsiliol may inhibit Ca2+ influx but stimulates Ca2+ release from intracellular stores [1]. Treatment with Cirsiliol reduces the proliferation of NSCLC cells through the suppression of radiation-induced Notch-1 expression [2].
In vivo	In the xenograft mouse model, tumor volume is significantly reduced by combinational treatment with irradiation and rhamnetin or cirsiliol compared with irradiation alone [2].

Molecular Weight	330.292
Formula	C17H14O7
CAS No.	34334-69-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Mustafa EH, et al. Effects of cirsiliol, a flavone isolated from Achillea fragrantissima, on rat isolated ileum. Gen Pharmacol. 1992 May;23(3):555-60. 2. Kang J, et al. Rhamnetin and cirsiliol induce radiosensitization and inhibition of epithelial-mesenchymal transition (EMT) by miR-34a-mediated suppression of Notch-1 expression in non-small cell lung cancer cell lines. J Biol Chem. 2013 Sep 20;288(38):27343-57.

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Keywords

Cirsiliol 34334-69-5 代谢 Lipoxygenase Inhibitor inhibitor inhibit

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