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Cephalexin monohydrate

Catalog No. T20022 CAS 23325-78-2

Synonyms: Cephalexin hydrate, Cephacillin hydrate, Cefalexin hydrate

Cephalexin monohydrate (Cephalexin hydrate) is an orally available semi-synthetic cephalosporin antibiotic with significant antimicrobial activity that inhibits bacterial proliferation by targeting penicillin-binding proteins (PBPs).

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Cephalexin monohydrate Chemical Structure

Cephalexin monohydrate, CAS 23325-78-2

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500 mg	In stock	$ 42.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Cephalexin monohydrate (Cephalexin hydrate) is an orally available semi-synthetic cephalosporin antibiotic with significant antimicrobial activity that inhibits bacterial proliferation by targeting penicillin-binding proteins (PBPs).
In vivo	In male Swiss-Webster mice infected with bacteria, cephalexin monohydrate (0-50 mg/kg; oral administration; for 3.5 hours) exhibited antibacterial activity against Streptococcus pyogenes, Streptococcus pneumoniae, Staphylococcus aureus, and several gram-negative species[2].

Synonyms	Cephalexin hydrate, Cephacillin hydrate, Cefalexin hydrate
Molecular Weight	365.4
Formula	C16H19N3O5S
CAS No.	23325-78-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 1 mg/mL (2.74 mM), Sonication is recommended.

DMSO: 5 mg/mL (13.68 mM), Sonication is recommended.

References and Literature

1. Cho H, et al. Beta-lactam antibiotics induce a lethal malfunctioning of the bacterial cell wall synthesis machinery. Cell. 2014 Dec 4;159(6):1300-11. 2. Buck RE, et, al. Cefadroxil, a new broad-spectrum cephalosporin. Antimicrob Agents Chemother. 1977 Feb;11(2):324-30. 3. Wang X, Qiu H, Liu X, Jiang S. [Separation of bases, phenols and pharmaceuticals on ionic liquid-modified silica stationary phase with pure water as mobile phase]. Se Pu. 2011 Mar;29(3):269-72. Chinese. PubMed PMID: 21657060. 4. Davis JL, Salmon JH, Papich MG. Pharmacokinetics and tissue fluid distribution of cephalexin in the horse after oral and i.v. administration. J Vet Pharmacol Ther. 2005 Oct;28(5):425-31. PubMed PMID: 16207304.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Cephalexin monohydrate 23325-78-2 Microbiology/Virology Antibiotic Cephalexin Cefibacter Cephalexin hydrate Cephacillin hydrate Cefalexin hydrate Cefalival inhibitor inhibit

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