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Cefpiramide sodium

Catalog No. T14923 CAS 74849-93-7

Synonyms: SM-1652, Wy-44635

Cefpiramide sodium (SM-1652; Wy-44635) is a Pseudomonas-active cephalosporin. It has a broad spectrum of antibacterial activity.

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Cefpiramide sodium, CAS 74849-93-7

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2 mg	5 days	$ 58.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Cefpiramide sodium (SM-1652; Wy-44635) is a Pseudomonas-active cephalosporin. It has a broad spectrum of antibacterial activity.
In vitro	Cefpiramide was moderately susceptible to hydrolysis by a variety of beta-lactamases from Gram-negative bacilli. Cefpiramide inhibited non-enterococcal streptococci, methicillin-susceptible staphylococci, Neisseria gonorrhoeae, N. meningitidis, and beta-lactamase-negative Haemophilus influenzae [1].
In vivo	Cefpiramide inhibited staphylococci and streptococci and had appreciable activity against Streptococcus faecalis and Listeria moncytogenes [3]. Pharmacokinetic studies in mice showed that cefpiramide attained a peak serum concentration of 12 micrograms/ml and a serum half-life of 40 min, which are higher than attained by cefoperazone with values of 4 micrograms/ml and 18 min. These factors may have caused the combined cefpiramide-gentamicin therapy to result in significantly improved survival rates in mice as well as in higher bactericidal titers than the cefoperazone-gentamicin combination [2].

Synonyms	SM-1652, Wy-44635
Molecular Weight	635.63
Formula	C25H24N8NaO7S2
CAS No.	74849-93-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 39 mg/mL (61.36 mM)

References and Literature

1. Barry AL, et al. Cefpiramide: comparative in-vitro activity and beta-lactamase stability. J Antimicrob Chemother. 1985 Sep;16(3):315-25. 2. Fu KP, et al. Therapeutic efficacy of cefpiramide and cefoperazone alone and in combination with gentamicin against pseudomonal infections in neutropenic mice. Chemotherapy. 1986;32(2):166-72. 3. Neu HC, et al. The in vitro activity and beta-lactamase stability of cefpiramide compared with other beta-lactam antibiotics. Diagn Microbiol Infect Dis. 1985 Nov;3(6):479-88.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Cefpiramide sodium 74849-93-7 Others SM 1652 SM-1652 Wy-44635 SM1652 inhibitor inhibit

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