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Caspase-3 Inhibitor I

Catalog No. TQ0146L CAS TQ0146L

Synonyms: Ac-DEVD-CHO acetate (169332-60-9 free base), 乙酰基-天冬氨酰-谷氨酰-缬氨酰-天冬氨醛, N-acetyl-asp-glu-val-asp-al

Caspase-3 Inhibitor I is a specific inhibitor of Caspase-3.

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Caspase-3 Inhibitor I, CAS TQ0146L

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Caspase-3 Inhibitor I is a specific inhibitor of Caspase-3.
In vitro	Pretreatment with the caspase-3 inhibitor Ac-DEVD-CHO or antioxidant NAC blocked SLNT-induced apoptosis[1]. The apoptosis of SP2/0 cells was blocked by a pan-caspase inhibitor Z-VAD-FMK and caspase-3 inhibitor Ac-DEVD-CHO[2].
In vivo	Compared with model group, in CI group, the concentrations of serum BUN were decreased significantly at all time points after operation and those of Cr were decreased significantly at 6 hours, then restored to those of the sham group at 12 hours and 24 hours; the concentrations of serum TNF-α, IL-6 were decreased and those of IL-10 elevated significantly at all time points[3].

Synonyms	Ac-DEVD-CHO acetate (169332-60-9 free base), 乙酰基-天冬氨酰-谷氨酰-缬氨酰-天冬氨醛, N-acetyl-asp-glu-val-asp-al
Molecular Weight	562.52
Formula	C22H34N4O13
CAS No.	TQ0146L

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: 40 mg/mL (79.61 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Wang J , Li W , Xiao H , et al. A polysaccharide from Lentinus edodes inhibits human colon cancer cell proliferation and suppresses tumor growth in athymic nude mice.[J]. Oncotarget, 2017, 8(1). 2. Junping Zhang, et al. Hypericin-mediated photodynamic therapy induces apoptosis of myoloma SP2/0 cells depended on caspase activity in vitro. Cancer Cell Int. 2015; 15: 58 3. Liu L X , Hu Z J , Li Y , et al. [The effect of caspase-3 inhibitor on the concentrations of serum inflammatory cytokines in sepsis related acute kidney injury induced by peritoneal cavity infection in mice].[J]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2010, 22(12):736-739.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Caspase-3 Inhibitor I TQ0146L 蛋白酶体凋亡 Caspase Ac-DEVD-CHO acetate (169332-60-9 free base) Caspase 3 Inhibitor I Caspase3 Inhibitor I N-acetyl-asp-glu-val-asp-al Inhibitor inhibitor inhibit

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