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Ac-DEVD-CHO acetate

Catalog No. TQ0146L CAS TQ0146L

Synonyms: Caspase-3 Inhibitor I, N-acetyl-asp-glu-val-asp-al, Ac-DEVD-CHO acetate (169332-60-9 free base)

Caspase-3 Inhibitor I (N-acetyl-asp-glu-val-asp-al) is a specific inhibitor of Caspase-3.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Ac-DEVD-CHO acetate, CAS TQ0146L

Pack Size	Availability	Price/USD
1 mg	In stock	$ 70.00
5 mg	In stock	$ 223.00
10 mg	In stock	$ 336.00
25 mg	In stock	$ 567.00
50 mg	In stock	Inquiry

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Purity: 98.54%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Caspase-3 Inhibitor I (N-acetyl-asp-glu-val-asp-al) is a specific inhibitor of Caspase-3.
In vitro	Pretreatment with the caspase-3 inhibitor Ac-DEVD-CHO or antioxidant NAC blocked SLNT-induced apoptosis[1]. The apoptosis of SP2/0 cells was blocked by a pan-caspase inhibitor Z-VAD-FMK and caspase-3 inhibitor Ac-DEVD-CHO[2].
In vivo	Compared with model group, in CI group, the concentrations of serum BUN were decreased significantly at all time points after operation and those of Cr were decreased significantly at 6 hours, then restored to those of the sham group at 12 hours and 24 hours; the concentrations of serum TNF-α, IL-6 were decreased and those of IL-10 elevated significantly at all time points[3].

Synonyms	Caspase-3 Inhibitor I, N-acetyl-asp-glu-val-asp-al, Ac-DEVD-CHO acetate (169332-60-9 free base)
Molecular Weight	562.52
Formula	C22H34N4O13
CAS No.	TQ0146L

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 40 mg/mL (79.61 mM)

References and Literature

1. Wang J , Li W , Xiao H , et al. A polysaccharide from Lentinus edodes inhibits human colon cancer cell proliferation and suppresses tumor growth in athymic nude mice.[J]. Oncotarget, 2017, 8(1). 2. Junping Zhang, et al. Hypericin-mediated photodynamic therapy induces apoptosis of myoloma SP2/0 cells depended on caspase activity in vitro. Cancer Cell Int. 2015; 15: 58 3. Liu L X , Hu Z J , Li Y , et al. [The effect of caspase-3 inhibitor on the concentrations of serum inflammatory cytokines in sepsis related acute kidney injury induced by peritoneal cavity infection in mice].[J]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2010, 22(12):736-739.

Citations

1. Wang Q, Guo S, Hu D, et al.Enhanced GSDME-mediated pyroptosis in Alzheimer’s disease.Neuroscience.2023

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Inhibitor Library Pyroptosis Compound Library Bioactive Compound Library Apoptosis Compound Library Protease Inhibitor Library Bioactive Compounds Library Max NO PAINS Compound Library Anti-Cancer Compound Library

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Related compounds with same targets

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ac-DEVD-CHO acetate TQ0146L Apoptosis Proteases/Proteasome Caspase 169332-60-9 free base Caspase-3 Inhibitor I N-acetyl-asp-glu-val-asp-al Ac-DEVD-CHO acetate (169332-60-9 free base) Ac-DEVD-CHO Acetate Caspase 3 Inhibitor I 169332-60-9 Caspase3 Inhibitor I inhibitor inhibit

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