Home Tools

Carbidine

Catalog No. T23854 CAS 33162-17-3

Synonyms: Carbidine dihydrochloride, Karbidin, Carbidin, Karbidine

Carbidine (Carbidin) is a derivative of gamma-carboline, an atypical antipsychotic drug. It reduces the inhibitory effect of DA on the 3H-DA release from synaptosomes of the nucleus accumbens septi and on the activity of tyrosine hydroxylase in vivo and in vitro.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Carbidine, CAS 33162-17-3

Pack Size	Availability	Price/USD
5 mg	In stock	$ 50.00
10 mg	In stock	$ 70.00
25 mg	In stock	$ 114.00
50 mg	In stock	$ 167.00
100 mg	In stock	$ 248.00
500 mg	In stock	$ 535.00
1 mL * 10 mM (in DMSO)	In stock	$ 59.00

Bulk Inquiry

Select Batch

Purity: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Carbidine (Carbidin) is a derivative of gamma-carboline, an atypical antipsychotic drug. It reduces the inhibitory effect of DA on the 3H-DA release from synaptosomes of the nucleus accumbens septi and on the activity of tyrosine hydroxylase in vivo and in vitro.
In vivo	After the administration of Carbidine(5 mg/kg, i.p.), the maximal IFC of Carbidine was found to be approximately 1 mu M 20-40 min after injection. Carbidine(1 mu M, i.p.) produces elevation of dopamine release not affecting sufficiently its metabolite dialysate levels. Carbidine(0.2 and 0.5 mg/kg, i.p.) stimulated locomotor activity of non-operated rats[1].

Synonyms	Carbidine dihydrochloride, Karbidin, Carbidin, Karbidine
Molecular Weight	275.217
Formula	C13H20Cl2N2
CAS No.	33162-17-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2.75 mg/mL (10 mM), Sonication is recommended.

References and Literature

1. Proskuriakova TV, Gurtovenko VM, Gorshkova EP. [Comparative evaluation of the effect of carbidine and levamisole on the E-rosette-forming activity of the lymphocytes in alcoholic intoxication]. Farmakol Toksikol. 1989 Jan-Feb;52(1):94-8. Russian. 2. Kudrin VS, et al. [Effect of the atypical neuroleptics carbidine and sulpiride on dopamine biosynthesis in the synaptosomes of the nucleus accumbens septi in rats]. Farmakol Toksikol. 1987 Mar-Apr;50(2):16-20. Russian. 3. Zharkovskiĭ AM, Klassen NE, Zharkovskiĭ TA. [Effect of carbidine on the dopamine and serotonin receptors of the central nervous system]. Biull Eksp Biol Med. 1985 Jun;99(6):700-2. Russian. 4. Gainetdinov RR, et al. Simultaneous monitoring of dopamine, its metabolites and trans-isomer of atypical neuroleptic drug carbidine concentrations in striatal dialysates of conscious rats. Prog Neuropsychopharmacol Biol Psychiatry. 1996 Feb;20(2):291-305.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Bioactive Compounds Library Max

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step Two: Enter the in vivo formulation

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

Calculate Reset

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculation

Molecular Weight Calculator

Mass

Concentration

Volume

Molecular Weight

Molarity Calculator allows you to calculate the

Mass of a compound required to prepare a solution of known volume and concentration
Volume of solution required to dissolve a compound of known mass to a desired concentration
Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Molecule Formula

Molecular Weight g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Carbidine 33162-17-3 Others Carbidine dihydrochloride Karbidin Carbidin Carbidine Dihydrochloride Karbidine inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.