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CYM50308

Catalog No. T15032 CAS 1345858-76-5

CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM and it shows 37-fold more selective for S1P4-R than S1P5-R.

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CYM50308, CAS 1345858-76-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 57.00
5 mg	In stock	$ 145.00
10 mg	In stock	$ 216.00
25 mg	In stock	$ 366.00
50 mg	In stock	$ 548.00
100 mg	In stock	$ 762.00
200 mg	In stock	$ 995.00
1 mL * 10 mM (in DMSO)	In stock	$ 158.00

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Purity: 99.63%

Purity: 99.43%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM and it shows 37-fold more selective for S1P4-R than S1P5-R.
Targets&IC50	S1P5:2100 nM（EC50）, S1P4:（EC50）56 nM
In vitro	CYM50308 shows low nanomolar S1P4-R agonist activity and exquisite selectivity over the other S1P-Rs subtypes. CYM50308 provides a valuable pharmacological tool to explore the effects of the S1P4-R signaling cascade and elucidate the molecular basis of the in vivo receptor function[1].

Molecular Weight	405.46
Formula	C20H21F2N3O2S
CAS No.	1345858-76-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 12 mg/mL (29.60 mM), Sonication is recommended.

References and Literature

1. Urbano M, et al. Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6739-45.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Bioactive Compounds Library Max Bioactive Compound Library

Related Products

Related compounds with same targets

VPC 23019 S1p receptor agonist 1 CYM-5541 Ponesimod PF-543 hydrochloride Opaganib 4-Deoxypyridoxine hydrochloride Phorbol 12-myristate 13-acetate

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Keywords

CYM50308 1345858-76-5 GPCR/G Protein S1P Receptor LPL Receptor ML248 Lysophospholipid Receptor selective S1P4-R ML-248 CYM 50308 receptor Inhibitor Potent inhibit CYM-50308 ML 248 inhibitor

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