Powder: -20°C for 3 years
In solvent: -80°C for 2 years
CVT-12012 is an orally bioavailable inhibitor of stearoyl-CoA desaturase (SCD; IC50 = 6.1 nM in HepG2 cells).
Description | CVT-12012 is an orally bioavailable inhibitor of stearoyl-CoA desaturase (SCD; IC50 = 6.1 nM in HepG2 cells). |
Targets&IC50 | human HEPG2:6.1 nM, rat microsomal:38 nM |
In vivo | CVT-12012 is highly potent in a human cell-based (HEPG2) SCD assay (IC(50)=6nM). This compound has 78% oral bioavailability in rats and is preferentially distributed into liver (76 times vs plasma) with relatively low brain penetration[1]. |
Molecular Weight | 434.41 |
Formula | C21H21F3N4O3? |
CAS No. | 1018675-35-8 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 125 mg/mL (287.75 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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CVT-12012 1018675-35-8 Metabolism Stearoyl-CoA Desaturase (SCD) CVT 12012 inhibit CVT12012 Inhibitor inhibitor