Home Tools

Cart

CORM-3

Catalog No. T6454 CAS 475473-26-8

Synonyms: CORM 3, (OC-6-44)-三羰基氯(甘氨酸基)钌, CORM3

CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

CORM-3, CAS 475473-26-8

Please contact us for prices and availability for the specification of product you are interested at.
Product consultation

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.
In vitro	CORM-3 protects against hypoxia-reoxygenation and oxidative stress by promoting CO release in cardiac cells. [1] CORM-3 attenuates the inflammatory response induced by LPS in RAW264.7 murine macrophages. [2] CORM-3 also uncouples mitochondrial respiration via interaction with the phosphate carrier. [4]
In vivo	CORM-3 (40 mg/kg i.p.) prolongs the survival of murine cardiac grafts and attenuates organ rejection in CBA mice transplanted with BALB/c hearts. [1] CORM-3 (20 mg/kg i.p.) decreases cellular infiltration, joint inflammation and destruction in a collagen-induced arthritis mouse model. [3]

Synonyms	CORM 3, (OC-6-44)-三羰基氯(甘氨酸基)钌, CORM3
Molecular Weight	294.61
Formula	C5H4ClNO5Ru
CAS No.	475473-26-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 129 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Clark JE, et al. Circ Res. 2003, 93(2), e2-8. 2. Sawle P, et al. Br J Pharmacol. 2005, 145(6), 800-810. 3. Ferrándiz ML, et al. Ann Rheum Dis. 2008 Sep;67(9):1211-7. 4. Long R, et al. Biochim Biophys Acta. 2014, 1837(1), 201-209. 5. Huang Y, et al. Carbon monoxide (CO) inhibits hydrogen peroxide (H2O2)-induced oxidative stress and the activation of NF-κB signaling in lens epithelial cells. Exp Eye Res. 2018 Jan;166:29-39. 6. Tian X, Liu X, Wang A, et al. Bioluminescence Imaging of Carbon Monoxide in Living Cells and Nude Mice Based on Pd0-Mediated Tsuji–Trost Reaction[J]. Analytical chemistry. 2018 May 1;90(9):5951-5958.

Citations

1. Tian X, Liu X, Wang A, et al. Bioluminescence Imaging of Carbon Monoxide in Living Cells and Nude Mice Based on Pd0-Mediated Tsuji–Trost Reaction. Analytical chemistry. 2018 May 1;90(9):5951-5958.

Related compound libraries

This product is contained In the following compound libraries：

Immunology/Inflammation Compound Library NF-κB Signaling Compound Library Ferroptosis Compound Library Anti-Fibrosis Compound Library Anti-Aging Compound Library Anti-Infection Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

Siegeskaurolic acid Nortrachelogenin Neoechinulin A Kaerophyllin Isoangustone A Broussonin A Alpinumisoflavone 2-Methoxystypandrone

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step Two: Enter the in vivo formulation

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

Calculate Reset

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculation

Molecular Weight Calculator

Mass

Concentration

Volume

Molecular Weight

Molarity Calculator allows you to calculate the

Mass of a compound required to prepare a solution of known volume and concentration
Volume of solution required to dissolve a compound of known mass to a desired concentration
Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Molecule Formula

Molecular Weight g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CORM-3 475473-26-8 NF-Kb信号通路免疫与炎症其他 NF-κB NOD-like Receptor (NLR) Others inhibit Inhibitor CORM3 Nuclear factor-kappaB Nuclear factor-κB CORM 3 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.