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CORM-3

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COA

CORM-3

Catalog No. T6454Cas No. 475473-26-8

CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.

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Pack Size	Price	Availability
5 mg	$30	In Stock
10 mg	$51	In Stock
25 mg	$84	In Stock
50 mg	$123	In Stock
100 mg	$182	In Stock
500 mg	$457	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock

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Product Introduction

Bioactivity

Description	CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.
In vitro	CORM-3 protects against hypoxia-reoxygenation and oxidative stress by promoting CO release in cardiac cells. [1] CORM-3 attenuates the inflammatory response induced by LPS in RAW264.7 murine macrophages. [2] CORM-3 also uncouples mitochondrial respiration via interaction with the phosphate carrier. [4]
In vivo	CORM-3 (40 mg/kg i.p.) prolongs the survival of murine cardiac grafts and attenuates organ rejection in CBA mice transplanted with BALB/c hearts. [1] CORM-3 (20 mg/kg i.p.) decreases cellular infiltration, joint inflammation and destruction in a collagen-induced arthritis mouse model. [3]
Alias	CORM3

Chemical Properties

Molecular Weight	294.61
Formula	C5H4ClNO5Ru
Cas No.	475473-26-8

Storage & Solubility Information

Storage

store at low temperature,store under nitrogen|Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (169.72 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3943 mL	16.9716 mL	33.9432 mL	169.7159 mL
5 mM	0.6789 mL	3.3943 mL	6.7886 mL	33.9432 mL
10 mM	0.3394 mL	1.6972 mL	3.3943 mL	16.9716 mL
20 mM	0.1697 mL	0.8486 mL	1.6972 mL	8.4858 mL
50 mM	0.0679 mL	0.3394 mL	0.6789 mL	3.3943 mL
100 mM	0.0339 mL	0.1697 mL	0.3394 mL	1.6972 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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