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CID 2011756

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Purity:100%

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COA HPLC HNMR LCMS

CID 2011756

Catalog No. T1863Cas No. 638156-11-3

CID 2011756 is an ATP-competitive and specific PKD1 inhibitor.

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Pack Size	Price	Availability
5 mg	$39	In Stock
10 mg	$72	In Stock
25 mg	$137	In Stock
50 mg	$247	In Stock
100 mg	$342	In Stock
500 mg	$827	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock

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Product Introduction

Bioactivity

Description	CID 2011756 is an ATP-competitive and specific PKD1 inhibitor.
Kinase Assay	Ub-PLA2 assay: Recombinant enzymes in 20 mM Tris-HCl, pH 8.0, 2 mM CaCl2 and 2 mM β-mercaptoethanol (DUB assay buffer) are preincubated with single doses or dose ranges of PR-619 or P22077 for 30 minutes in a 96 well plate before the addition of Ub-PLA2 and NBD C6-HPC. The liberation of a fluorescent product within the linear range of the assay is monitored at room temperature using a fluorescence plate reader. Vehicle (2%(v/v) DMSO) and 10 mM N-ethylmaleimide are included as controls. Where ≥60% inhibition is observed, EC50 values are determined using a sigmoidal dose response equation.
Alias	CID2011756, CID-2011756

Chemical Properties

Molecular Weight	396.87
Formula	C22H21ClN2O3
Cas No.	638156-11-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 15 mg/mL (37.8 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5197 mL	12.5986 mL	25.1972 mL	125.9858 mL
5 mM	0.5039 mL	2.5197 mL	5.0394 mL	25.1972 mL
10 mM	0.2520 mL	1.2599 mL	2.5197 mL	12.5986 mL
20 mM	0.1260 mL	0.6299 mL	1.2599 mL	6.2993 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc