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CHMFL-FLT3-122

Catalog No. T27011 CAS 1839150-56-9

Synonyms: CHMFLFLT3122, CHMFL FLT3 122

CHMFL-FLT3-122 is a potent and orally available FLT3 kinase inhibitor used to treat FLT3-ITD positive acute myeloid leukemia. CHMFL-FLT3-122 significantly suppressed the tumor growth in MV4-11 cell inoculated xenograft model (50 mg/kg) without exhibiting obvious toxicity in vivo.

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CHMFL-FLT3-122, CAS 1839150-56-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 98.00
5 mg	In stock	$ 239.00
10 mg	In stock	$ 356.00
25 mg	In stock	$ 588.00
50 mg	In stock	$ 857.00
100 mg	In stock	$ 1,180.00
500 mg	In stock	$ 2,360.00

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Purity: 99.56%

ee: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	CHMFLFLT3122, CHMFL FLT3 122
Molecular Weight	471.55
Formula	C26H29N7O2
CAS No.	1839150-56-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

1eq. HCl: 90.0 mg/mL (190.9 mM)

DMSO: 90.0 mg/mL (190.9 mM)

References and Literature

1. Li X, et al. Discovery of (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2-(dimethylamino)ethanone (CHMFL-FLT3-122) as a Potent and Orally Available FLT3 Kinase Inhibitor for FLT3-ITD Positive Acute Myeloid Leukemia. J Med Chem. 2015 Dec 24;58(24):9625-38.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Tyrosine Kinase Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library Kinase Inhibitor Library

Related Products

Related compounds with same targets

5Z-7-Oxozeaenol UNC2025 2HCl (1429881-91-3(free base)) Tyrphostin AG1296 BRD7389 Allitinib tosylate NVP-AEW541 UNC2541 BPR1J-097 hydrochloride (1327167-19-0(free base))

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CHMFL-FLT3-122 1839150-56-9 Angiogenesis Tyrosine Kinase/Adaptors FLT CHMFLFLT-3122 CHMFLFLT3122 CHMFL FLT3 122 CHMFLFLT 3122 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.