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CB-6644

🥰Excellent
Catalog No. T10693Cas No. 2316817-88-4

CB-6644 is a small molecule inhibitor of the ATPase activity of the RUVBL1/2 complex. It specifically interacts with RUVBL1/2 in cancer cells and blocks the ATPase activity of RUVBL1/2 with a half-maximal inhibitory concentration (IC50) of 15 nM[1].

CB-6644

CB-6644

🥰Excellent
Purity: 99.85%
Catalog No. T10693Cas No. 2316817-88-4
CB-6644 is a small molecule inhibitor of the ATPase activity of the RUVBL1/2 complex. It specifically interacts with RUVBL1/2 in cancer cells and blocks the ATPase activity of RUVBL1/2 with a half-maximal inhibitory concentration (IC50) of 15 nM[1].
Pack SizePriceAvailabilityQuantity
1 mg$228In Stock
5 mg$463In Stock
10 mg$666In Stock
25 mg$987In Stock
50 mg$1,380In Stock
100 mg$1,860In Stock
200 mg$2,490In Stock
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Bulk & Custom
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:99.85%
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COA FNMR HNMR HPLC LCMS

Product Introduction

Bioactivity
Description
CB-6644 is a small molecule inhibitor of the ATPase activity of the RUVBL1/2 complex. It specifically interacts with RUVBL1/2 in cancer cells and blocks the ATPase activity of RUVBL1/2 with a half-maximal inhibitory concentration (IC50) of 15 nM[1].
Targets&IC50
RUVBL1/2:15 nM
In vitro
METHODS: HCT116, NCI-1975, and HT29 cells were treated with CB-6644 (100nM-500nM) and allowed to form colonies within 3 weeks.
RESULTS CB-6644 was able to effectively kill cells with an EC50 range of 41 ~ 785 nM. [1]
In vivo
METHODS: Plasma concentrations and tumor growth were measured in nude female mice or after a single intravenous dose (0.5 mg/kg) of CB-6644.
RESULTS CB-6644 can significantly inhibit tumor growth and has little effect on body weight. [1]
Chemical Properties
Molecular Weight573.06
FormulaC29H34ClFN4O5
Cas No.2316817-88-4
SmilesCCOc1cc(F)c(Cl)cc1C(=O)NCC(C)(C)CC(=O)Nc1c(COC)n2CCCc3ccccc3-n2c1=O
Relative Density.1.34 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 1.43 mg/mL (2.5 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7450 mL8.7251 mL17.4502 mL87.2509 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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Keywords

RUVBL1/2InhibitorinhibitCB-6644CB6644CB 6644
Related Tags: buy CB-6644 | purchase CB-6644 | CB-6644 cost | order CB-6644 | CB-6644 chemical structure | CB-6644 in vivo | CB-6644 in vitro | CB-6644 formula | CB-6644 molecular weight
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