Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CB-6644 is a selective inhibitor of the RUVBL1/2 complex and blocks the ATPase activity of RUVBL1/2 (IC50 = 15 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 228.00 | |
5 mg | In stock | $ 579.00 | |
10 mg | In stock | $ 829.00 | |
25 mg | In stock | $ 1,260.00 | |
50 mg | In stock | $ 1,680.00 | |
100 mg | In stock | $ 2,280.00 | |
500 mg | In stock | $ 4,590.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 786.00 |
Description | CB-6644 is a selective inhibitor of the RUVBL1/2 complex and blocks the ATPase activity of RUVBL1/2 (IC50 = 15 nM). |
Targets&IC50 | 123 cell lines:41 to 785 nM(EC50), RUVBL1/2:15 nM |
In vitro | CB-6644 (20 μM) interacts with the RUVBL1/2 complex in Ramos cells. CB-6644 (0.001-10 μM; 72 hours) potently kills 123 cell lines (EC50: 41 to 785 nM). |
In vivo | CB-6644 (150 mg/kg, p.o., 30 days of treatment for SCID-beige mice bearing RPMI8226 xenograft models, 10 days of treatment for SCID-beige mice bearing Ramos xenograft models) has antitumor activity in xenograft tumor models. The tumor growth inhibitions (TGIs) are 68 and 81%, respectively in Ramos xenograft models and RPMI8226 xenograft models. |
Molecular Weight | 573.06 |
Formula | C29H34ClFN4O5 |
CAS No. | 2316817-88-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 88 mg/mL (153.56 mM)
You can also refer to dose conversion for different animals. More
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CB-6644 2316817-88-4 Others CB6644 Inhibitor CB 6644 inhibit inhibitor