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CAY10773

Catalog No. T36882 CAS 1648546-79-5

CAY10773 is a derivative of the ferroptosis inducer sorafenib .1It selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells (IC50s = 5.77, 5.21 and 3.97 μM, respectively) over non-cancerous HCV-29 cells (IC50= 23.19 μM). CAY10773 induces apoptosis in T24 cells when used at concentrations ranging from 2 to 6 μM but induces ferroptosis at concentrations greater than or equal to 6 μM with 10 hour or longer incubation times. It increases the production of reactive oxygen species (ROS) and decreases the mitochondrial membrane potential in T24 cells. CAY10773 (≥6 μM) also induces autophagy with incubation times longer than eight hours.

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CAY10773, CAS 1648546-79-5

Pack Size	Availability	Price/USD
1 mg	35 days	$ 170.00
5 mg	35 days	$ 630.00
10 mg	35 days	$ 1,170.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	438.31
Formula	C22H17Cl2N5O
CAS No.	1648546-79-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMF: 1 mg/mL

DMSO: 1 mg/mL

References and Literature

1. Chen, J.-N., Li, T., Cheng, L., et al.Synthesis and in vitro anti-bladder cancer activity evaluation of quinazolinyl-arylurea derivativesEur. J. Med. Chem.205112661(2020)

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CAY10773 1648546-79-5 CAY-10773 CAY 10773 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.