Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 μM). SIRT3 is involved in modulating metabolic homeostasis as a NAD+-dependent protein deacetylase in the mitochondria. SIRT3 functions as either an oncogene or tumor suppressor, depending on cancer cell type. High SIRT3 expression in patient-derived esophageal cancer tissues is associated with shorter survival and, in mice, downregulation leads to a lower tumor load. In contrast, low SIRT3 expression in patient-derived breast cancer cells is correlated with shorter survival.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 35 days | $ 348.00 | |
10 mg | 35 days | $ 595.00 | |
25 mg | 35 days | $ 1,330.00 |
Description | CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 μM). SIRT3 is involved in modulating metabolic homeostasis as a NAD+-dependent protein deacetylase in the mitochondria. SIRT3 functions as either an oncogene or tumor suppressor, depending on cancer cell type. High SIRT3 expression in patient-derived esophageal cancer tissues is associated with shorter survival and, in mice, downregulation leads to a lower tumor load. In contrast, low SIRT3 expression in patient-derived breast cancer cells is correlated with shorter survival. |
Molecular Weight | 397.25 |
Formula | C21H14Cl2N2O2 |
CAS No. | 388086-13-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL
Ethanol: Slightly soluble
DMF: 10 mg/mL
DMSO:PBS(pH7.2) (1:1): 0.5 mg/mL
You can also refer to dose conversion for different animals. More
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CAY10722 388086-13-3 CAY 10722 CAY-10722 inhibitor inhibit