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Brilliant Black BN

Catalog No. T18928 CAS 2519-30-4

Synonyms: E 151

Brilliant Black BN (E 151) is an azo dye and a food colorant. It is a promising antiviral agent against EV71 infection via inhibiting the interaction between EV71 and its cellular uncoating factor cyclophilin A.

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Brilliant Black BN, CAS 2519-30-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 36.00
10 mg	In stock	$ 51.00
25 mg	In stock	$ 80.00
50 mg	In stock	$ 116.00
100 mg	In stock	$ 171.00
1 mL * 10 mM (in DMSO)	In stock	$ 54.00

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Biological Description

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Storage & Solubility Information

Description	Brilliant Black BN (E 151) is an azo dye and a food colorant. It is a promising antiviral agent against EV71 infection via inhibiting the interaction between EV71 and its cellular uncoating factor cyclophilin A.
Targets&IC50	EV71 (various strains):2.39 µM- 28.12 µM (IC50)
In vitro	Brilliant black BN inhibited the infection EV71 -GFP at a concentration of 300 μM. Brilliant black BN exhibits the inhibition of EV71 -GFP as a dose-dependent manner in infected RD cells (IC50: 10.1 μM). Brilliant black BN is able to inhibit all tested 28 EV71, CVA16, and CVA6 strains. In rhabdomyosarcoma cells, 50% inhibitory concentration 29 of the dye E151 for various strains of EV71 ranged from 2.39 μM to 28.12 μM, whereas its 50% cytotoxic concentration is 1870 μM [2].
In vivo	Brilliant black BN (i.p.; 200 mg/kg; 14 days)exhibits mild illness with clinical scores less than 3 and subsequently recovered when compared with PBS-group. All E151 270 treated mice are completely protected throughout the experiment [2].

Synonyms	E 151
Molecular Weight	867.68
Formula	C28H17N5Na4O14S4
CAS No.	2519-30-4

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 123 mg/mL (141.75 mM), Sonification is recommended.

References and Literature

1. Lang W, et al. Biodecolorization of a food azo dye by the deep sea Dermacoccus abyssi MT1.1(T) strain from the Mariana Trench.J Environ Manage. 2014 Jan;132:155-64. 2. Meng T, et al. In Vitro and In Vivo Inhibition of the Infectivity of Human Enterovirus 71 by a Sulfonated Food Azo Dye, Brilliant Black BN.J Virol. 2019 Aug 13;93(17).

Related compound libraries

This product is contained In the following compound libraries：

Human Metabolite Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Brilliant Black BN 2519-30-4 Microbiology/Virology Others Virus Protease HFMD HEVs additive,contagious HEV EV71,infection HRVs antiviral,food HRV Rhinovirus Enterovirus E-151 E 151 inhibit E151 Inhibitor disease inhibitor

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