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Bimatoprost

Catalog No. T2538 CAS 155206-00-1

Synonyms: AGN 192024

Bimatoprost (AGN 192024) is a cloprostenol-derived amide that is used as an antihypertensive agent in the treatment of open-angle glaucoma and ocular hypertension.

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Bimatoprost, CAS 155206-00-1

Pack Size	Availability	Price/USD
2 mg	In stock	$ 30.00
5 mg	In stock	$ 48.00
10 mg	In stock	$ 81.00
25 mg	In stock	$ 150.00
50 mg	In stock	$ 271.00
100 mg	In stock	$ 458.00
1 mL * 10 mM (in DMSO)	In stock	$ 53.00

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Purity: 100%

Purity: 99.81%

Purity: 98%

Biological Description

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Storage & Solubility Information

Description	Bimatoprost (AGN 192024) is a cloprostenol-derived amide that is used as an antihypertensive agent in the treatment of open-angle glaucoma and ocular hypertension.
In vitro	Bimatoprost is an effective prostaglandin FP receptor agonist, capable of directly inducing a robust and rapid return of calcium ions to baseline levels. It directly activates FP prostaglandin receptors in rats, mice, and humans.
In vivo	Bimatoprost displaces [3H] prostaglandin F (2alpha) binding to FP receptors with a Ki of 6.31 μM. It rapidly mobilizes intracellular calcium in 3T3 mouse fibroblasts expressing FP receptors (EC50: 2.2 μM) and human embryonic kidney cells with human FP receptors (EC50: 2.94 μM). Bimatoprost upregulates Cyr61 expression in feline irises and mildly stimulates aqueous humor outflow rate, increasing it by 13% during the day and 14% at night, while reducing tonographic outflow by 26%, thereby lowering intraocular pressure.

Synonyms	AGN 192024
Molecular Weight	415.57
Formula	C25H37NO4
CAS No.	155206-00-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 34 mg/mL (81.8 mM)

Ethanol: 77 mg/mL (185.3 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Brubaker RF, et al. Surv Ophthalmol, 2001, 45 Suppl 4, S347-351. 2. Sharif NA, et al. Eur J Pharmacol, 2001, 432(2-3), 211-213. 3. Liang Y, et al. J Biol Chem, 2003, 278(29), 27267-27277. 4. Spada CS, et al. Exp Eye Res, 2005, 80(1), 135-145. 5. Kelly CR, et al. J Pharmacol Exp Ther, 2003, 304(1), 238-245.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-COVID-19 Compound Library Coagulation and Anticoagulation Compound Library Bioactive Lipid Compound Library FDA-Approved Drug Library EMA Approved Drug Library GPCR Compound Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Bimatoprost 155206-00-1 GPCR/G Protein Immunology/Inflammation Prostaglandin Receptor AGN 192024 inhibit Inhibitor AGN-192024 AGN192024 inhibitor

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