keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 113.00 | |
2 mg | In stock | $ 168.00 | |
5 mg | In stock | $ 289.00 | |
10 mg | In stock | $ 463.00 | |
25 mg | In stock | $ 748.00 | |
50 mg | In stock | $ 987.00 | |
100 mg | In stock | $ 1,380.00 |
Description | BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM). |
Targets&IC50 | α4β7:2 μM, α4β1:4 nM |
In vitro | BIO-1211 does not show activity against α1β1, α5β1, α6β1, αLβ2 and αIIbβ3[2]. |
In vivo | In naive, C57BL/6 mice, BIO-1211 exhibited a considerable depletion in the EAE clinical score, which correlated with decreased expression of TNF-α, IL-17, IFN-γ and pervade of CD11b+ and CD45+ cells into the cerebral cortex. BIO-1211 resulted in reduced cytokines expression, leukocyte trafficking, and inhibition of inflammatory responses in a dose-independent manner[1]. |
Molecular Weight | 708.8 |
Formula | C36H48N6O9 |
CAS No. | 187735-94-0 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (352.71 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BIO-1211 187735-94-0 Cytoskeletal Signaling Integrin inhibit BIO1211 BIO 1211 Inhibitor inhibitor