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BIO-1211

Name: BIO-1211
Brand: TargetMol
SKU: T21868
Price: 113 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21868Cas No. 187735-94-0

BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM).

BIO-1211

🥰Excellent

Purity: 99.33%

Catalog No. T21868Cas No. 187735-94-0

BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM).

Pack Size	Price	Availability
1 mg	$113	In Stock
2 mg	$168	In Stock
5 mg	$289	In Stock
10 mg	$463	In Stock
25 mg	$748	In Stock
50 mg	$987	In Stock
100 mg	$1,380	In Stock

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Batch Information

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Purity:99.33%

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COA HPLC

Product Introduction

Bioactivity

Description	BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM).
Targets&IC50	α4β7:2 μM, α4β1:4 nM
In vitro	BIO-1211 does not show activity against α1β1, α5β1, α6β1, αLβ2 and αIIbβ3[2].
In vivo	In naive, C57BL/6 mice, BIO-1211 exhibited a considerable depletion in the EAE clinical score, which correlated with decreased expression of TNF-α, IL-17, IFN-γ and pervade of CD11b+ and CD45+ cells into the cerebral cortex. BIO-1211 resulted in reduced cytokines expression, leukocyte trafficking, and inhibition of inflammatory responses in a dose-independent manner[1].

Chemical Properties

Molecular Weight	708.8
Formula	C₃₆H₄₈N₆O₉
Cas No.	187735-94-0
Smiles	CC(C)C[C@H](NC(=O)Cc1ccc(NC(=O)Nc2ccccc2C)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(O)=O
Relative Density.	1.306 g/cm3 (Predicted)
Color	White
Appearance	Solid
Sequence	Leu-Asp-Val-Pro
Sequence Short	LDVP

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (352.71 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (7.05 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4108 mL	7.0542 mL	14.1084 mL	70.5418 mL
5 mM	0.2822 mL	1.4108 mL	2.8217 mL	14.1084 mL
10 mM	0.1411 mL	0.7054 mL	1.4108 mL	7.0542 mL
20 mM	0.0705 mL	0.3527 mL	0.7054 mL	3.5271 mL
50 mM	0.0282 mL	0.1411 mL	0.2822 mL	1.4108 mL
100 mM	0.0141 mL	0.0705 mL	0.1411 mL	0.7054 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc