Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BAY-598 is a selective inhibitor of SMYD2 with IC50 values of 27 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 52.00 | |
5 mg | In stock | $ 107.00 | |
10 mg | In stock | $ 169.00 | |
25 mg | In stock | $ 263.00 | |
50 mg | In stock | $ 446.00 | |
100 mg | In stock | $ 719.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 123.00 |
Description | BAY-598 is a selective inhibitor of SMYD2 with IC50 values of 27 nM. |
Targets&IC50 | SMYD2:27 nM |
In vitro | BAY-598 treatment blocked in vitro methylation of MAPKAPK3 by SMYD2 but had no activity against the SMYD2-related KMT SMYD3, which methylated its substrate, MAP3K2, irrespective of the presence of BAY-598.?BAY-598 treatment reduced the growth of Kras;p53 mutant PDAC cells after 9 d in culture but had little impact on the growth of Kras;p53;Smyd2 mutant cells , further supporting the specificity of this small molecule inhibitor of SMYD2 as well as a role for SMYD2 in promoting the growth of PDAC cells[1]. |
Molecular Weight | 525.34 |
Formula | C22H20Cl2F2N6O3 |
CAS No. | 1906919-67-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (237.94 mM)
You can also refer to dose conversion for different animals. More
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BAY-598 1906919-67-2 Chromatin/Epigenetic Histone Methyltransferase BAY 598 Inhibitor BAY598 inhibit inhibitor