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Azlocillin sodium salt

Catalog No. T0049 CAS 37091-65-9

Synonyms: Sodium azlocillin, Azlocillin sodium

Azlocillin sodium, an acylampicillin, is a broad-spectrum antibiotics

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Azlocillin sodium salt Chemical Structure

Azlocillin sodium salt, CAS 37091-65-9

Pack Size	Availability	Price/USD
200 mg	In stock	$ 30.00
500 mg	In stock	$ 48.00
1 g	In stock	$ 81.00
1 mL * 10 mM (in DMSO)	In stock	$ 53.00

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Purity: 97.63%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Azlocillin sodium, an acylampicillin, is a broad-spectrum antibiotics

In vitro

Azlocillin (12.5 μg/mL) inhibits over 75% of the isolates of Pseudomonas aeruginosa. Azlocillin (12.5 μg/mL) is also active against indole-negative and -positive Proteus spp., inhibiting 98 and 71%, respectively. Azlocillin is more active than mezlocillin, ticarcillin, and carbenicillin and as active as BLP-1654 against isolates of P. aeruginosa. [1] The acyl side chains of Azlocillin have an ureido-(urea) structurehence the name 'ureidopenicillins' or, more specifically, 'acylureidopenicillins.' In vitro studies against P. aeruginosa demonstrates that piperacillin has activity that is twice that of azlocillin, 4 times that of mezlocillin and ticarcillin, and about 8 times that of carbenicillin. Azlocillin produces elongated bacterial forms with delayed or no lysis in morphologic studies. [2] Azlocillin has MICs of 12.5 μg/mL on Pseudomonas aeruginosa. Azlocillin (3.125 μg/mL) results in a reduction in the rate of growth but no bactericidal phase on Pseudomonas aeruginosa. Azlocillin decreases an initial lag phase with increasing drug concentration. At the lower concentration of tobramycin (0.5 μg/ml), the combinations with both the high and the low concentrations of Azlocillin are more effective than the individual components on Pseudomonas aeruginosa. [3] Isolates with derepression of AmpC enzyme are one to two doubling dilutions more resistant to azlocillin than are those in which increased efflux or impermeability is inferred. Those with secondary β-lactamases are mostly (12/14 cases) susceptible to ceftazidime at 4 mg/L, but are amongst the most resistant to Azlocillin (MIC ≥128 mg/L in 10/14 cases). [4]

Synonyms	Sodium azlocillin, Azlocillin sodium
Molecular Weight	483.47
Formula	C20H22N5NaO6S
CAS No.	37091-65-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90 mg/mL (186.2 mM)

H2O: 89 mg/mL (184.1 mM)

Ethanol: 3 mg/mL (6.19 mM)

References and Literature

1. Stewart D, et al. Antimicrob Agents Chemother, 1977, 11(5), 865-870. 2. Wright AJ, et al. Mayo Clin Proc, 1999, 74(3), 290-307. 3. McFarland MM, et al. Antimicrob Agents Chemother, 1994, 38(6), 1271-1276. 4. Livermore DM, et al. J Antimicrob Chemother, 1999, 43(4), 517-522. 5. Johnson PR, et al. J Antimicrob Chemother, 1992, 30(2), 203-214.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Parasitic Compound Library Drug Repurposing Compound Library FDA-Approved Drug Library Antibiotics Library Bioactive Compounds Library Max NO PAINS Compound Library Covalent Inhibitor Library FDA-Approved & Pharmacopeia Drug Library Bioactive Compound Library Approved Drug Library

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Related compounds with same targets

Amifloxacin Lysostaphin Cetylpyridinium chloride monohydrate Syringic acid Aspoxicillin Phanquinone Pyrazinamide LED209

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Keywords

Azlocillin sodium salt 37091-65-9 Microbiology/Virology Antibiotic Antibacterial Parasite Sodium azlocillin piperacillin Azlocillin sodium Inhibitor penicillin Azlocillin Bacterial inhibit similar mezlocillin inhibitor

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