Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Azido-PEG6-NHS ester is a cleavable 6 unit polyethylene glycol (PEG) linker, commonly employed in the synthesis of antibody-drug conjugates (ADCs)[1]. Additionally, it serves as a PEG- and alkyl/ether based linker for the synthesis of proteolysis targeting chimeras (PROTACs)[2].
Description | Azido-PEG6-NHS ester is a cleavable 6 unit polyethylene glycol (PEG) linker, commonly employed in the synthesis of antibody-drug conjugates (ADCs)[1]. Additionally, it serves as a PEG- and alkyl/ether based linker for the synthesis of proteolysis targeting chimeras (PROTACs)[2]. |
In vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
Molecular Weight | 476.48 |
Formula | C19H32N4O10 |
CAS No. | 2055014-64-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Azido-PEG6-NHS ester 2055014-64-5 Others Azido-PEG-6-NHS ester Azido PEG6 NHS ester AzidoPEG6NHS ester inhibitor inhibit