Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Azido-PEG4-CH2-Boc is a four-unit cleavable polyethylene glycol (PEG) linker compound employed in the synthesis of antibody-drug conjugates (ADCs)[1] and PROTACs[2]. This linker is characterized by its azide functional group and PEG backbone, facilitating the conjugation of drugs to antibodies in ADC development and enabling the synthesis of PROTACs utilizing PEG and alkyl/ether moieties.
Description | Azido-PEG4-CH2-Boc is a four-unit cleavable polyethylene glycol (PEG) linker compound employed in the synthesis of antibody-drug conjugates (ADCs)[1] and PROTACs[2]. This linker is characterized by its azide functional group and PEG backbone, facilitating the conjugation of drugs to antibodies in ADC development and enabling the synthesis of PROTACs utilizing PEG and alkyl/ether moieties. |
In vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
Molecular Weight | 333.38 |
Formula | C14H27N3O6 |
CAS No. | 864681-04-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Azido-PEG4-CH2-Boc 864681-04-9 Others Azido PEG4 CH2 Boc Azido-PEG-4-CH2-Boc AzidoPEG4CH2Boc inhibitor inhibit