Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Adriforant hydrochloride is an antagonist of histamine H4 receptor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | Inquiry | |
50 mg | 6-8 weeks | Inquiry | |
100 mg | 6-8 weeks | Inquiry |
Description | Adriforant hydrochloride is an antagonist of histamine H4 receptor. |
Targets&IC50 | H4 receptor bind:ki:2.4 nM , H4 receptor func:1.56 nM (ki) |
In vitro | Adriforant in vitro IC50 on human native isolated eosinophils assessing actin polymerisation is 1.16 nM and assuming need 10 times the IC50 for >90% receptor occupancy (and therefore near complete inhibition of the response) suggested a concentration of 12 nM. The data in the whole blood GAFS assay demonstrates that the imetit induced shape change is completely blocked at a total blood concentration of 30 nM (which correcting for PPB and blood partitioning equates to approximately 10 nM free). For the purpose of dose projection and safety margin calculation, a Ceff/Cmin concentration of 10-15 nM is used |
Synonyms | PF-3893787 hydrochloride |
Molecular Weight | 371.74 |
Formula | C13H25Cl3N6 |
CAS No. | 2096455-90-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 83.33 mg/mL (224.16 mM)
You can also refer to dose conversion for different animals. More
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Adriforant hydrochloride 2096455-90-0 Others PF-3893787 hydrochloride PF-3893787 Hydrochloride PF3893787 Hydrochloride Adriforant Hydrochloride PF 3893787 Hydrochloride inhibitor inhibit