Shopping Cart

Remove All
Your shopping cart is currently empty

AUZ 454

Name: AUZ 454
Brand: TargetMol
SKU: T6866
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T6866Cas No. 853299-07-7

Alias K03861

AUZ 454 (K03861) is a type II CDK2 inhibitor with Kd values of 50 nM for CDK2(WT), 18.6 nM for CDK2(C118L), 15.4 nM for CDK2(A144C), and 9.7 nM for CDK2(C118L/A144C).

AUZ 454

🥰Excellent

Purity: 99.59%

Catalog No. T6866Alias K03861Cas No. 853299-07-7

AUZ 454 (K03861) is a type II CDK2 inhibitor with Kd values of 50 nM for CDK2(WT), 18.6 nM for CDK2(C118L), 15.4 nM for CDK2(A144C), and 9.7 nM for CDK2(C118L/A144C).

Pack Size	Price	Availability
5 mg	$43	In Stock
10 mg	$70	In Stock
25 mg	$148	In Stock
50 mg	$223	In Stock
100 mg	$358	In Stock
200 mg	$497	In Stock
1 mL x 10 mM (in DMSO)	$59	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.59%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	AUZ 454 (K03861) is a type II CDK2 inhibitor with Kd values of 50 nM for CDK2(WT), 18.6 nM for CDK2(C118L), 15.4 nM for CDK2(A144C), and 9.7 nM for CDK2(C118L/A144C).
Targets&IC50	CDK2 (C118L):18.6 nM(Kd), CDK2 (WT):50 nM(Kd), CDK2 (A144C):15.4 nM(Kd), CDK2 (C118L/A144C):9.7 nM(Kd)
In vitro	K03861 inhibits CDK2 activity by competing with binding of activating cyclins. [1]
Synonyms	K03861

Chemical Properties

Molecular Weight	501.5
Formula	C₂₄H₂₆F₃N₇O₂
Cas No.	853299-07-7
Smiles	CN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4ccnc(N)n4)cc3)cc2C(F)(F)F)CC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 12 mg/mL (23.93 mM), Sonication is recommended.

DMSO: 93 mg/mL (185.44 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.58 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9940 mL	9.9701 mL	19.9402 mL	99.7009 mL
5 mM	0.3988 mL	1.9940 mL	3.9880 mL	19.9402 mL
10 mM	0.1994 mL	0.9970 mL	1.9940 mL	9.9701 mL
20 mM	0.0997 mL	0.4985 mL	0.9970 mL	4.9850 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0399 mL	0.1994 mL	0.3988 mL	1.9940 mL
100 mM	0.0199 mL	0.0997 mL	0.1994 mL	0.9970 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc