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AT-1002 TFA (835872-35-0 free base)

Catalog No. T13560L CAS T13560L

Synonyms: AT-1002 TFA

AT-1002 TFA is a tight junction regulator and absorption enhancer. It is a 6-mer synthetic peptide.

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AT-1002 TFA (835872-35-0 free base) Chemical Structure

AT-1002 TFA (835872-35-0 free base), CAS T13560L

Pack Size	Availability	Price/USD
5 mg	Inquiry	$ 223.00
10 mg	Inquiry	$ 398.00
50 mg	Inquiry	$ 1,190.00
100 mg	Inquiry	$ 1,850.00
200 mg	Inquiry	Inquiry
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Biological Description

Chemical Properties

Storage & Solubility Information

Description

AT-1002 TFA is a tight junction regulator and absorption enhancer. It is a 6-mer synthetic peptide.

In vitro

AT-1002 reversibly increases the paracellular transport of molecules across the epithelial barrier. AT-1002 can undergo Cys-Cys dimerization [1]. Undifferentiated Caco-2 cells are treated with AT-1002 (0 to 5 mg/mL, 3 or 24 hours) and viability is assessed by measuring cellular ATP content. Treatment with AT-1002 for up to 3 h does not affect cell viability at any concentration. In particular, the viability of Caco-2 cells is not affected by 5 mg/mL AT-1002. AT-1002 reduces cell viability after 24 h at concentrations of 2.5 mg/mL and higher. However, the cells remain viable after 24 h if the cells are washed after exposure to AT-1002 for 3 h [2].

Synonyms	AT-1002 TFA
Molecular Weight	821.91
Formula	C34H54F3N9O9S
CAS No.	T13560L

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Li M, et al. Structure-activity relationship studies of permeability modulating peptide AT-1002. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4584-6. 2. Gopalakrishnan S, et al. Mechanism of action of ZOT-derived peptide AT-1002, a tight junction regulator and absorption enhancer. Int J Pharm. 2009 Jan 5;365(1-2):121-30.

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Keywords

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