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ARRY-380 (analog )

ARRY-380 (analog )
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Purity:98.22%
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ARRY-380 (analog )

Catalog No. T2518Cas No. 937265-83-3
ARRY-380 analog (HER2-Inhibitor-1) is a potent and selective HER2 inhibitor.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$30In Stock
2 mg$42In Stock
5 mg$68In Stock
10 mg$112In Stock
25 mg$189In Stock
50 mg$281In Stock
100 mg Inquiry In Stock
1 mL x 10 mM (in DMSO)$88In Stock
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Product Introduction

Bioactivity
Description
ARRY-380 analog (HER2-Inhibitor-1) is a potent and selective HER2 inhibitor.
Kinase Assay
The Millipore Kinase Profiler service is used to generate general selectivity data for SCH 900776 against a broad range of serine/threonine and tyrosine kinases. Assays are typically run at two concentrations of SCH 900776 (0.5 and 5 μM), at a fixed (10 μM) concentration of ATP. Data are provided as percent activity remaining, relative to uninhibited controls.
AliasHER2-Inhibitor-1, ARRY380, ARRY-380 analog
Chemical Properties
Molecular Weight569.63
FormulaC29H27N7O4S
Cas No.937265-83-3
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 91 mg/mL(159.8 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7555 mL8.7776 mL17.5553 mL87.7763 mL
5 mM0.3511 mL1.7555 mL3.5111 mL17.5553 mL
10 mM0.1756 mL0.8778 mL1.7555 mL8.7776 mL
20 mM0.0878 mL0.4389 mL0.8778 mL4.3888 mL
50 mM0.0351 mL0.1756 mL0.3511 mL1.7555 mL
100 mM0.0176 mL0.0878 mL0.1756 mL0.8778 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg,each TargetMol | Animal experiments animal weighs 20 g, and the dosage volume is 100 μL. A total of TargetMol | Animal experiments 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL.
Mother liquor preparation method: 2 mg of drug dissolved in 50 μLDMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μLDMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μLTween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

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