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ARRY-380 (analog )

Catalog No. T2518 CAS 937265-83-3

Synonyms: HER2-Inhibitor-1, ARRY380, ARRY-380 analog

ARRY-380 analog (HER2-Inhibitor-1) is a potent and selective HER2 inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

ARRY-380 (analog ), CAS 937265-83-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 48.00
2 mg	In stock	$ 70.00
5 mg	In stock	$ 117.00
10 mg	In stock	$ 187.00
25 mg	In stock	$ 316.00
50 mg	In stock	$ 469.00
100 mg	In stock	$ 687.00
1 mL * 10 mM (in DMSO)	In stock	$ 147.00

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Purity: 98.22%

Biological Description

Chemical Properties

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Description	ARRY-380 analog (HER2-Inhibitor-1) is a potent and selective HER2 inhibitor.
Targets&IC50	HER2:8 nM
Kinase Assay	The Millipore Kinase Profiler service is used to generate general selectivity data for SCH 900776 against a broad range of serine/threonine and tyrosine kinases. Assays are typically run at two concentrations of SCH 900776 (0.5 and 5 μM), at a fixed (10 μM) concentration of ATP. Data are provided as percent activity remaining, relative to uninhibited controls.

Synonyms	HER2-Inhibitor-1, ARRY380, ARRY-380 analog
Molecular Weight	569.63
Formula	C29H27N7O4S
CAS No.	937265-83-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 91 mg/mL(159.8 mM)

References and Literature

1. Madala SK, et al. Am J Respir Cell Mol Biol. 2012 Mar;46(3):380-8.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Highly Selective Inhibitor Library Membrane Protein-targeted Compound Library Tyrosine Kinase Inhibitor Library Anti-Cancer Clinical Compound Library Inhibitor Library Preclinical Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ARRY-380 (analog ) 937265-83-3 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR HER ARRY-380 HER2-Inhibitor-1 Inhibitor HER1 analog ARRY380 (analog ) Epidermal growth factor receptor ARRY 380 (analog ) ATP-competitive ARRY380 ARRY-380 analog ErbB-1 ARRY 380 inhibit inhibitor

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