Powder: -20°C for 3 years | In solvent: -80°C for 1 year
9-Decyn-1-ol is an alkyl/ether-based PROTAC linker suitable for synthesizing PROTACs. It serves as a conjugation agent to combine GDC-0068 and Lenalidomide, resulting in the formation of INY-03-041. INY-03-041 is a potent and highly selective pan-Akt degrader that operates through the PROTAC mechanism. It effectively inhibits Akt1, Akt2, and Akt3 with IC50 values of 2.0 nM, 6.8 nM, and 3.5 nM, respectively[1].
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Description | 9-Decyn-1-ol is an alkyl/ether-based PROTAC linker suitable for synthesizing PROTACs. It serves as a conjugation agent to combine GDC-0068 and Lenalidomide, resulting in the formation of INY-03-041. INY-03-041 is a potent and highly selective pan-Akt degrader that operates through the PROTAC mechanism. It effectively inhibits Akt1, Akt2, and Akt3 with IC50 values of 2.0 nM, 6.8 nM, and 3.5 nM, respectively[1]. |
In vitro | 9-Decyn-1-ol facilitates the conjugation of GDC-0068 with Lenalidomide, producing INY-03-041. This compound is a comprehensive AKT degrader, formed through the linkage of the ATP-competitive AKT inhibitor GDC-0068 and Lenalidomide using a connector[1]. |
Molecular Weight | 154.25 |
Formula | C10H18O |
CAS No. | 17643-36-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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9-Decyn-1-ol 17643-36-6 Others 9Decyn1ol 9 Decyn 1 ol inhibitor inhibit